Hypokalemia and salbutamol therapy in asthma

Chih Hsing Hung; Der Ming Chu; Chih Lu Wang; Kuender D. Yang

doi:10.1002/(SICI)1099-0496(199901)27:1<27::AID-PPUL6>3.0.CO;2-P

Hypokalemia and salbutamol therapy in asthma

Chih Hsing Hung^*
, Der Ming Chu
, Chih Lu Wang
, Kuender D. Yang

^*Corresponding author for this work

School of Medicine

Triservice General Hospital Taiwan

Research output: Contribution to journal › Journal Article › peer-review

28 Scopus citations

Abstract

Hypokalemia is a common side effect in adult asthmatic patients on beta 2 adrenergic therapy. There is limited information in regard to hypokalemia and its relation to the clinical responses following administration of beta 2 agonist therapy in children with asthma. We observed that salbutamol inhalation significantly improved asthmatic symptoms as demonstrated by increases in peak expiratory flow (PEF: 122.37 ± 75.38 vs. 152.59 ± 80.29; P < 0.001) and venous oxygen tension (Pv,O₂: 33.24 ± 4.95 vs. 58.16 ± 2.31; P < 0.001), and decreases in respiratory rate (RR: 36.39 ± 3.78 vs. 28.62 ± 3.12; P < 0.01), clinical scores (CS: 3.59 ± 1.28 vs. 1.59 ± 0.71), and venous PCO₂ tensions (Pv,CO₂: 40.84 ± 2.67 vs. 34.75 ± 2.31; P < 0.001). Salbutamol-induced hypokalemia was correlated with a decrease in RR, and an increase of Pv,O₂ and PEF. These findings suggest that the same mechanism is involved in eliciting hypokalemia and bronchodilatation.

Original language	English
Pages (from-to)	27-31
Number of pages	5
Journal	Pediatric Pulmonology
Volume	27
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1099-0496(199901)27:1<27::AID-PPUL6>3.0.CO;2-P
State	Published - 01 1999

Keywords

Bronchodilators
Hypokalemia
Peak expiratory flow
Salbutamol
Venous blood gases

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/(SICI)1099-0496(199901)27:1<27::AID-PPUL6>3.0.CO;2-P

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title = "Hypokalemia and salbutamol therapy in asthma",

abstract = "Hypokalemia is a common side effect in adult asthmatic patients on beta 2 adrenergic therapy. There is limited information in regard to hypokalemia and its relation to the clinical responses following administration of beta 2 agonist therapy in children with asthma. We observed that salbutamol inhalation significantly improved asthmatic symptoms as demonstrated by increases in peak expiratory flow (PEF: 122.37 ± 75.38 vs. 152.59 ± 80.29; P < 0.001) and venous oxygen tension (Pv,O2: 33.24 ± 4.95 vs. 58.16 ± 2.31; P < 0.001), and decreases in respiratory rate (RR: 36.39 ± 3.78 vs. 28.62 ± 3.12; P < 0.01), clinical scores (CS: 3.59 ± 1.28 vs. 1.59 ± 0.71), and venous PCO2 tensions (Pv,CO2: 40.84 ± 2.67 vs. 34.75 ± 2.31; P < 0.001). Salbutamol-induced hypokalemia was correlated with a decrease in RR, and an increase of Pv,O2 and PEF. These findings suggest that the same mechanism is involved in eliciting hypokalemia and bronchodilatation.",

keywords = "Bronchodilators, Hypokalemia, Peak expiratory flow, Salbutamol, Venous blood gases",

author = "Hung, \{Chih Hsing\} and Chu, \{Der Ming\} and Wang, \{Chih Lu\} and Yang, \{Kuender D.\}",

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AU - Chu, Der Ming

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AU - Yang, Kuender D.

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N2 - Hypokalemia is a common side effect in adult asthmatic patients on beta 2 adrenergic therapy. There is limited information in regard to hypokalemia and its relation to the clinical responses following administration of beta 2 agonist therapy in children with asthma. We observed that salbutamol inhalation significantly improved asthmatic symptoms as demonstrated by increases in peak expiratory flow (PEF: 122.37 ± 75.38 vs. 152.59 ± 80.29; P < 0.001) and venous oxygen tension (Pv,O2: 33.24 ± 4.95 vs. 58.16 ± 2.31; P < 0.001), and decreases in respiratory rate (RR: 36.39 ± 3.78 vs. 28.62 ± 3.12; P < 0.01), clinical scores (CS: 3.59 ± 1.28 vs. 1.59 ± 0.71), and venous PCO2 tensions (Pv,CO2: 40.84 ± 2.67 vs. 34.75 ± 2.31; P < 0.001). Salbutamol-induced hypokalemia was correlated with a decrease in RR, and an increase of Pv,O2 and PEF. These findings suggest that the same mechanism is involved in eliciting hypokalemia and bronchodilatation.

AB - Hypokalemia is a common side effect in adult asthmatic patients on beta 2 adrenergic therapy. There is limited information in regard to hypokalemia and its relation to the clinical responses following administration of beta 2 agonist therapy in children with asthma. We observed that salbutamol inhalation significantly improved asthmatic symptoms as demonstrated by increases in peak expiratory flow (PEF: 122.37 ± 75.38 vs. 152.59 ± 80.29; P < 0.001) and venous oxygen tension (Pv,O2: 33.24 ± 4.95 vs. 58.16 ± 2.31; P < 0.001), and decreases in respiratory rate (RR: 36.39 ± 3.78 vs. 28.62 ± 3.12; P < 0.01), clinical scores (CS: 3.59 ± 1.28 vs. 1.59 ± 0.71), and venous PCO2 tensions (Pv,CO2: 40.84 ± 2.67 vs. 34.75 ± 2.31; P < 0.001). Salbutamol-induced hypokalemia was correlated with a decrease in RR, and an increase of Pv,O2 and PEF. These findings suggest that the same mechanism is involved in eliciting hypokalemia and bronchodilatation.

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KW - Salbutamol

KW - Venous blood gases

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Hypokalemia and salbutamol therapy in asthma

Abstract

Keywords

UN SDGs

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