Hypopharyngeal cancer treatment based on definitive radiotherapy: Who is suitable for laryngeal preservation?

S. W. Chen*, M. H. Tsai, S. N. Yang, J. A. Liang, A. C. Shiau, F. J. Lin

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

13 Scopus citations

Abstract

Aims: To investigate prognostic factors for survival and locoregional control in patients with stage I-IVA hypopharyngeal cancer treated with laryngeal preservation radiotherapy. Methods: This study was a retrospective analysis of 108 patients with stage I-IVA squamous cell carcinoma of the hypopharynx, treated with laryngeal preservation radiotherapy. Actuarial survival, disease-specific survival and local relapse-free survival were calculated, and multivariate analyses were performed using Cox's proportional hazards model. Results: After a median follow-up duration of 39 months, the five-year local relapse-free survival rate was 35 per cent for all patients, 66 per cent for those with stage I-II disease, 46 per cent for those with stage III disease and 20 per cent for those with stage IVA disease (p = 0.004). Multivariate analyses showed that tumour and node stages were independent prognostic factors. Conclusions: Patients with stage I-II disease were suitable for laryngeal preservation radiotherapy. For most patients with stage III-IVA disease, other than those who were T1 N1 or T2 N1, the treatment results were poor.

Original languageEnglish
Pages (from-to)506-512
Number of pages7
JournalJournal of Laryngology and Otology
Volume122
Issue number5
DOIs
StatePublished - 05 2008
Externally publishedYes

Keywords

  • Carcinoma
  • Pharynx Neoplasms
  • Prognosis
  • Radiotherapy

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