Hypoxia-induced lncRNA RP11-390F4.3 promotes epithelial-mesenchymal transition (EMT) and metastasis through upregulating EMT regulators

Pei Hua Peng; Joseph Chieh-Yu Lai; Kai Wen Hsu; Kou Juey Wu

doi:10.1016/j.canlet.2020.04.014

Hypoxia-induced lncRNA RP11-390F4.3 promotes epithelial-mesenchymal transition (EMT) and metastasis through upregulating EMT regulators

Pei Hua Peng, Joseph Chieh-Yu Lai, Kai Wen Hsu, Kou Juey Wu^*

^*Corresponding author for this work

Graduate Institute of Clinical Medical Sciences

Research output: Contribution to journal › Journal Article › peer-review

55 Scopus citations

Abstract

Hypoxia-induced long noncoding RNAs (lncRNAs) have been shown to induce tumor metastasis. However, lncRNAs that are regulated by hypoxia/HIF-1α and subsequently control the expression of multiple epithelial-mesenchymal transition (EMT) regulators have not been identified. To identify such lncRNAs, analysis of RNA-sequencing datasets was performed. The lncRNA RP11-390F4.3 was shown to be induced by hypoxia and directly activated by HIF-1α. Overexpression of lncRNA RP11-390F4.3 induced EMT and metastasis. LncRNA RP11-390F4.3 was essential for hypoxia-induced EMT and metastasis. LncRNA RP11-390F4.3 overexpression induced the expression of multiple EMT regulators. This report demonstrates that LncRNA RP11-390F4.3 is induced by hypoxia/HIF-1α and is essential for hypoxia-induced EMT and metastasis via the activation of multiple EMT regulators.

Original language	English
Pages (from-to)	35-45
Number of pages	11
Journal	Cancer Letters
Volume	483
DOIs	https://doi.org/10.1016/j.canlet.2020.04.014
State	Published - 28 07 2020

Bibliographical note

Publisher Copyright:
© 2020

Keywords

Epithelial-mesenchymal transition
Hypoxia
Metastasis
lncRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2020.04.014

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@article{3b46954e6bb5446aba5ec8fb0d9e36a7,

title = "Hypoxia-induced lncRNA RP11-390F4.3 promotes epithelial-mesenchymal transition (EMT) and metastasis through upregulating EMT regulators",

abstract = "Hypoxia-induced long noncoding RNAs (lncRNAs) have been shown to induce tumor metastasis. However, lncRNAs that are regulated by hypoxia/HIF-1α and subsequently control the expression of multiple epithelial-mesenchymal transition (EMT) regulators have not been identified. To identify such lncRNAs, analysis of RNA-sequencing datasets was performed. The lncRNA RP11-390F4.3 was shown to be induced by hypoxia and directly activated by HIF-1α. Overexpression of lncRNA RP11-390F4.3 induced EMT and metastasis. LncRNA RP11-390F4.3 was essential for hypoxia-induced EMT and metastasis. LncRNA RP11-390F4.3 overexpression induced the expression of multiple EMT regulators. This report demonstrates that LncRNA RP11-390F4.3 is induced by hypoxia/HIF-1α and is essential for hypoxia-induced EMT and metastasis via the activation of multiple EMT regulators.",

keywords = "Epithelial-mesenchymal transition, Hypoxia, Metastasis, lncRNA",

author = "Peng, \{Pei Hua\} and \{Chieh-Yu Lai\}, Joseph and Hsu, \{Kai Wen\} and Wu, \{Kou Juey\}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = jul,

day = "28",

doi = "10.1016/j.canlet.2020.04.014",

language = "英语",

volume = "483",

pages = "35--45",

journal = "Cancer Letters",

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TY - JOUR

T1 - Hypoxia-induced lncRNA RP11-390F4.3 promotes epithelial-mesenchymal transition (EMT) and metastasis through upregulating EMT regulators

AU - Peng, Pei Hua

AU - Chieh-Yu Lai, Joseph

AU - Hsu, Kai Wen

AU - Wu, Kou Juey

PY - 2020/7/28

Y1 - 2020/7/28

N2 - Hypoxia-induced long noncoding RNAs (lncRNAs) have been shown to induce tumor metastasis. However, lncRNAs that are regulated by hypoxia/HIF-1α and subsequently control the expression of multiple epithelial-mesenchymal transition (EMT) regulators have not been identified. To identify such lncRNAs, analysis of RNA-sequencing datasets was performed. The lncRNA RP11-390F4.3 was shown to be induced by hypoxia and directly activated by HIF-1α. Overexpression of lncRNA RP11-390F4.3 induced EMT and metastasis. LncRNA RP11-390F4.3 was essential for hypoxia-induced EMT and metastasis. LncRNA RP11-390F4.3 overexpression induced the expression of multiple EMT regulators. This report demonstrates that LncRNA RP11-390F4.3 is induced by hypoxia/HIF-1α and is essential for hypoxia-induced EMT and metastasis via the activation of multiple EMT regulators.

AB - Hypoxia-induced long noncoding RNAs (lncRNAs) have been shown to induce tumor metastasis. However, lncRNAs that are regulated by hypoxia/HIF-1α and subsequently control the expression of multiple epithelial-mesenchymal transition (EMT) regulators have not been identified. To identify such lncRNAs, analysis of RNA-sequencing datasets was performed. The lncRNA RP11-390F4.3 was shown to be induced by hypoxia and directly activated by HIF-1α. Overexpression of lncRNA RP11-390F4.3 induced EMT and metastasis. LncRNA RP11-390F4.3 was essential for hypoxia-induced EMT and metastasis. LncRNA RP11-390F4.3 overexpression induced the expression of multiple EMT regulators. This report demonstrates that LncRNA RP11-390F4.3 is induced by hypoxia/HIF-1α and is essential for hypoxia-induced EMT and metastasis via the activation of multiple EMT regulators.

KW - Epithelial-mesenchymal transition

KW - Hypoxia

KW - Metastasis

KW - lncRNA

UR - https://www.scopus.com/pages/publications/85084057071

U2 - 10.1016/j.canlet.2020.04.014

DO - 10.1016/j.canlet.2020.04.014

M3 - 文章

C2 - 32353468

AN - SCOPUS:85084057071

SN - 0304-3835

VL - 483

SP - 35

EP - 45

JO - Cancer Letters

JF - Cancer Letters

ER -

Hypoxia-induced lncRNA RP11-390F4.3 promotes epithelial-mesenchymal transition (EMT) and metastasis through upregulating EMT regulators

Abstract

Bibliographical note

Keywords

UN SDGs

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