Hypoxia-regulated target genes implicated in tumor metastasis

Ya Ping Tsai, Kou Juey Wu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

172 Scopus citations

Abstract

Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-mesenchymal transition (EMT) that is one of the crucial mechanisms to cause early stage of tumor metastasis. To have a better understanding of the mechanism of hypoxia-regulated metastasis, various hypoxia/HIF-1α- regulated target genes are categorized into different classes including transcription factors, histone modifiers, enzymes, receptors, kinases, small GTPases, transporters, adhesion molecules, surface molecules, membrane proteins, and microRNAs. Different roles of these target genes are described with regards to their relationship to hypoxia-induced metastasis. We hope that this review will provide a framework for further exploration of hypoxia/HIF-1α- regulated target genes and a comprehensive view of the metastatic picture induced by hypoxia.

Original languageEnglish
Article number102
JournalJournal of Biomedical Science
Volume19
Issue number1
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • Epithelial-mesenchymal transition
  • Hypoxia
  • Hypoxia-inducible factor
  • Metastasis
  • Target genes

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