Identification of genetic alterations in upper urinary tract urothelial carcinoma in end-stage renal disease patients

Ching Fang Wu, See Tong Pang, Jia Jen Shee, Phei Lang Chang, Cheng Keng Chuang, Chih Shou Chen, Shuen Kuei Liao, Wen Hui Weng*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

18 Scopus citations


Clinical presentations of end-stage renal disease (ESRD) patients on dialysis with upper urinary tract urothelial carcinoma (UUT-UC) are different from those with normal renal function. The pathogenesis remains unknown. We investigated the pathogenetic influence of chromosomal aberrations in patient on dialysis with UUT-UC. The chromosomal aberrations of UUT-UC specimens from seven dialysis patients were assessed by conventional comparative genomic hybridization (cCGH). Subsequently, we further investigated 20 cases by whole genome and fine-tiling oligonucleotide array-based CGH to demonstrate gains and losses, and compared with the clinicopathologic background. The chromosomal aberrations in UUT-UC specimens from dialysis patients were more complex than in bladder urothelial carcinoma (B-UC). Our data showed that gains at 5p, 7, 19q, and losses at 4q, 9p, and 15q are common in UUT-UC of ESRD patients. Gains in regions associated with DNA repair genes were noted in this study. High-stage and high-grade tumors displayed more copy number variants. In addition, female ESRD patients with UUT-UC had more frequent chromosomal aberrations than their male counterparts. In conclusion, unique chromosomal aberrations were indentified in UUT-UC in ESRD patients.

Original languageEnglish
Pages (from-to)928-934
Number of pages7
JournalGenes Chromosomes and Cancer
Issue number10
StatePublished - 10 2010


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