Identifying hepatitis C virus: endemic areas and estimating the viral antibody prevalence based on the prevalence of ALT elevation.

JC Chiang; Chun-Yen Lin; JH Wang; KM Kee; PF Chen; YD Chen; LS Tsai; TH Chen; SN Lu

doi:10.1016/j.trstmh.2009.03.027

Identifying hepatitis C virus: endemic areas and estimating the viral antibody prevalence based on the prevalence of ALT elevation.

JC Chiang
, Chun-Yen Lin
, JH Wang
, KM Kee
, PF Chen
, YD Chen
, LS Tsai
, TH Chen
, SN Lu

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

5 Scopus citations

Abstract

To evaluate the validity of predicting the prevalence of antibodies to hepatitis C virus (anti-HCV) based on the prevalence of alanine transaminase (ALT) elevation (>40IU/l), we conducted a community-based study. In total, 56698 individuals underwent health examinations in 2004. Another 43738 subjects in 2005 were the validation set. It should be valid to predict the prevalence of anti-HCV in villages (>25 participants) by the prevalence of ALT elevation. The equation was anti-HCV (%)=(% of ALT elevation - 6%)/65% (n=487 villages, R(2)=0.58). Villages with prevalence of ALT elevation >13% had a high probability of being HCV-endemic (anti-HCV >10%). The sensitivity and specificity were 73.6 and 74.6%, respectively. By the validation set, the positive and negative predictive values were 52.0% and 79.4%, respectively. Clinical and epidemiological deductions of the equation were that baseline of ALT elevation was 6% and two-thirds of anti-HCV-positive subjects had elevated ALT.

Original language	American English
Pages (from-to)	917-923
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	103
Issue number	9
DOIs	https://doi.org/10.1016/j.trstmh.2009.03.027
State	Published - 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aged
Alanine Transaminase/blood
Biological Markers/blood
Endemic Diseases
Female
Hepacivirus/immunology
Hepacivirus/isolation & purification
Hepatitis B Surface Antigens/blood
Hepatitis C Antibodies/blood
Hepatitis C/epidemiology
Hepatitis C/immunology
Humans
Male
Middle Aged
Predictive Value of Tests
Regression Analysis
Sensitivity and Specificity
Taiwan/epidemiology

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10.1016/j.trstmh.2009.03.027

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@article{6edf74f9eef742c49bb8f4ff942ee048,

title = "Identifying hepatitis C virus: endemic areas and estimating the viral antibody prevalence based on the prevalence of ALT elevation.",

abstract = "To evaluate the validity of predicting the prevalence of antibodies to hepatitis C virus (anti-HCV) based on the prevalence of alanine transaminase (ALT) elevation (>40IU/l), we conducted a community-based study. In total, 56698 individuals underwent health examinations in 2004. Another 43738 subjects in 2005 were the validation set. It should be valid to predict the prevalence of anti-HCV in villages (>25 participants) by the prevalence of ALT elevation. The equation was anti-HCV (\%)=(\% of ALT elevation - 6\%)/65\% (n=487 villages, R(2)=0.58). Villages with prevalence of ALT elevation >13\% had a high probability of being HCV-endemic (anti-HCV >10\%). The sensitivity and specificity were 73.6 and 74.6\%, respectively. By the validation set, the positive and negative predictive values were 52.0\% and 79.4\%, respectively. Clinical and epidemiological deductions of the equation were that baseline of ALT elevation was 6\% and two-thirds of anti-HCV-positive subjects had elevated ALT.",

keywords = "Aged, Alanine Transaminase/blood, Biological Markers/blood, Endemic Diseases, Female, Hepacivirus/immunology, Hepacivirus/isolation \& purification, Hepatitis B Surface Antigens/blood, Hepatitis C Antibodies/blood, Hepatitis C/epidemiology, Hepatitis C/immunology, Humans, Male, Middle Aged, Predictive Value of Tests, Regression Analysis, Sensitivity and Specificity, Taiwan/epidemiology",

author = "JC Chiang and Chun-Yen Lin and JH Wang and KM Kee and PF Chen and YD Chen and LS Tsai and TH Chen and SN Lu",

year = "2009",

doi = "10.1016/j.trstmh.2009.03.027",

language = "American English",

volume = "103",

pages = "917--923",

journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",

issn = "0035-9203",

publisher = "Oxford University Press",

number = "9",

}

Chiang, JC, Lin, C-Y, Wang, JH, Kee, KM, Chen, PF, Chen, YD, Tsai, LS, Chen, TH & Lu, SN 2009, 'Identifying hepatitis C virus: endemic areas and estimating the viral antibody prevalence based on the prevalence of ALT elevation.', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 103, no. 9, pp. 917-923. https://doi.org/10.1016/j.trstmh.2009.03.027

TY - JOUR

T1 - Identifying hepatitis C virus: endemic areas and estimating the viral antibody prevalence based on the prevalence of ALT elevation.

AU - Chiang, JC

AU - Lin, Chun-Yen

AU - Wang, JH

AU - Kee, KM

AU - Chen, PF

AU - Chen, YD

AU - Tsai, LS

AU - Chen, TH

AU - Lu, SN

PY - 2009

Y1 - 2009

N2 - To evaluate the validity of predicting the prevalence of antibodies to hepatitis C virus (anti-HCV) based on the prevalence of alanine transaminase (ALT) elevation (>40IU/l), we conducted a community-based study. In total, 56698 individuals underwent health examinations in 2004. Another 43738 subjects in 2005 were the validation set. It should be valid to predict the prevalence of anti-HCV in villages (>25 participants) by the prevalence of ALT elevation. The equation was anti-HCV (%)=(% of ALT elevation - 6%)/65% (n=487 villages, R(2)=0.58). Villages with prevalence of ALT elevation >13% had a high probability of being HCV-endemic (anti-HCV >10%). The sensitivity and specificity were 73.6 and 74.6%, respectively. By the validation set, the positive and negative predictive values were 52.0% and 79.4%, respectively. Clinical and epidemiological deductions of the equation were that baseline of ALT elevation was 6% and two-thirds of anti-HCV-positive subjects had elevated ALT.

AB - To evaluate the validity of predicting the prevalence of antibodies to hepatitis C virus (anti-HCV) based on the prevalence of alanine transaminase (ALT) elevation (>40IU/l), we conducted a community-based study. In total, 56698 individuals underwent health examinations in 2004. Another 43738 subjects in 2005 were the validation set. It should be valid to predict the prevalence of anti-HCV in villages (>25 participants) by the prevalence of ALT elevation. The equation was anti-HCV (%)=(% of ALT elevation - 6%)/65% (n=487 villages, R(2)=0.58). Villages with prevalence of ALT elevation >13% had a high probability of being HCV-endemic (anti-HCV >10%). The sensitivity and specificity were 73.6 and 74.6%, respectively. By the validation set, the positive and negative predictive values were 52.0% and 79.4%, respectively. Clinical and epidemiological deductions of the equation were that baseline of ALT elevation was 6% and two-thirds of anti-HCV-positive subjects had elevated ALT.

KW - Aged

KW - Alanine Transaminase/blood

KW - Biological Markers/blood

KW - Endemic Diseases

KW - Female

KW - Hepacivirus/immunology

KW - Hepacivirus/isolation & purification

KW - Hepatitis B Surface Antigens/blood

KW - Hepatitis C Antibodies/blood

KW - Hepatitis C/epidemiology

KW - Hepatitis C/immunology

KW - Humans

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Regression Analysis

KW - Sensitivity and Specificity

KW - Taiwan/epidemiology

U2 - 10.1016/j.trstmh.2009.03.027

DO - 10.1016/j.trstmh.2009.03.027

M3 - Journal Article

C2 - 19403151

SN - 0035-9203

VL - 103

SP - 917

EP - 923

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 9

ER -

Identifying hepatitis C virus: endemic areas and estimating the viral antibody prevalence based on the prevalence of ALT elevation.

Abstract

UN SDGs

Keywords

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