Imaging of regional metabolic activity by 18F-FDG/PET in rats with transient cerebral ischemia

Ying Kai Fu; Chia Jung Chang; Kuan Yin Chen; Li Chung Hwang; Kuo Hung Wu; Kang Wei Chang; Meei Ling Jan; Chia Chieh Chen; Chih Hsien Chang

doi:10.1016/j.apradiso.2009.03.002

Imaging of regional metabolic activity by ¹⁸F-FDG/PET in rats with transient cerebral ischemia

Ying Kai Fu^*, Chia Jung Chang, Kuan Yin Chen, Li Chung Hwang, Kuo Hung Wu, Kang Wei Chang, Meei Ling Jan, Chia Chieh Chen, Chih Hsien Chang

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

14 Scopus citations

Abstract

Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that ¹⁸F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with ¹⁸F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents.

Original language	English
Pages (from-to)	1743-1747
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	67
Issue number	10
DOIs	https://doi.org/10.1016/j.apradiso.2009.03.002
State	Published - 10 2009
Externally published	Yes

Keywords

F-FDG
MicroPET
Rat ischemia model

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10.1016/j.apradiso.2009.03.002

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title = "Imaging of regional metabolic activity by 18F-FDG/PET in rats with transient cerebral ischemia",

abstract = "Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that 18F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with 18F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents.",

keywords = "F-FDG, MicroPET, Rat ischemia model",

author = "Fu, {Ying Kai} and Chang, {Chia Jung} and Chen, {Kuan Yin} and Hwang, {Li Chung} and Wu, {Kuo Hung} and Chang, {Kang Wei} and Jan, {Meei Ling} and Chen, {Chia Chieh} and Chang, {Chih Hsien}",

year = "2009",

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volume = "67",

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journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

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T1 - Imaging of regional metabolic activity by 18F-FDG/PET in rats with transient cerebral ischemia

AU - Fu, Ying Kai

AU - Chang, Chia Jung

AU - Chen, Kuan Yin

AU - Hwang, Li Chung

AU - Wu, Kuo Hung

AU - Chang, Kang Wei

AU - Jan, Meei Ling

AU - Chen, Chia Chieh

AU - Chang, Chih Hsien

PY - 2009/10

Y1 - 2009/10

N2 - Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that 18F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with 18F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents.

AB - Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that 18F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with 18F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents.

KW - F-FDG

KW - MicroPET

KW - Rat ischemia model

UR - http://www.scopus.com/inward/record.url?scp=68949219587&partnerID=8YFLogxK

U2 - 10.1016/j.apradiso.2009.03.002

DO - 10.1016/j.apradiso.2009.03.002

M3 - 文章

C2 - 19372040

AN - SCOPUS:68949219587

SN - 0969-8043

VL - 67

SP - 1743

EP - 1747

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 10

ER -

Imaging of regional metabolic activity by ¹⁸F-FDG/PET in rats with transient cerebral ischemia

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Keywords

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