Imaging the availability of serotonin transporter in rat brain with I-ADAM and small-animal SPECT

Li Chung Hwang*, Chia Jung Chang, Hsueh Hsuan Liu, Hung Chun Kao, Shih Ying Lee, Meei Ling Jan, Chia Chieh Chen

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

9 Scopus citations

Abstract

Imaging serotonin transporters during antidepressant treatment in small animals is a useful tool for preclinical study during drug development. In this work, we aimed to demonstrate the feasibility of using I-ADAM and small-animal SPECT to monitor serotonin transporter availabilities in rat brains prior to and after administration of a selective serotonin re-uptake inhibitor.

Original languageEnglish
Pages (from-to)615-621
Number of pages7
JournalNuclear Medicine Communications
Volume28
Issue number8
DOIs
StatePublished - 08 2007
Externally publishedYes

Keywords

  • Serotonin transporter
  • Small-animal SPECT

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