Imaging the availability of serotonin transporter in rat brain with I-ADAM and small-animal SPECT

Li Chung Hwang; Chia Jung Chang; Hsueh Hsuan Liu; Hung Chun Kao; Shih Ying Lee; Meei Ling Jan; Chia Chieh Chen

doi:10.1097/MNM.0b013e32825a67cb

Imaging the availability of serotonin transporter in rat brain with I-ADAM and small-animal SPECT

Li Chung Hwang^*
, Chia Jung Chang
, Hsueh Hsuan Liu
, Hung Chun Kao
, Shih Ying Lee
, Meei Ling Jan
, Chia Chieh Chen

^*Corresponding author for this work

Institute of Nuclear Energy Research Taiwan

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

Abstract

Imaging serotonin transporters during antidepressant treatment in small animals is a useful tool for preclinical study during drug development. In this work, we aimed to demonstrate the feasibility of using I-ADAM and small-animal SPECT to monitor serotonin transporter availabilities in rat brains prior to and after administration of a selective serotonin re-uptake inhibitor.

Original language	English
Pages (from-to)	615-621
Number of pages	7
Journal	Nuclear Medicine Communications
Volume	28
Issue number	8
DOIs	https://doi.org/10.1097/MNM.0b013e32825a67cb
State	Published - 08 2007
Externally published	Yes

Keywords

Serotonin transporter
Small-animal SPECT

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10.1097/MNM.0b013e32825a67cb

Cite this

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abstract = "Imaging serotonin transporters during antidepressant treatment in small animals is a useful tool for preclinical study during drug development. In this work, we aimed to demonstrate the feasibility of using I-ADAM and small-animal SPECT to monitor serotonin transporter availabilities in rat brains prior to and after administration of a selective serotonin re-uptake inhibitor.",

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AU - Hwang, Li Chung

AU - Chang, Chia Jung

AU - Liu, Hsueh Hsuan

AU - Kao, Hung Chun

AU - Lee, Shih Ying

AU - Jan, Meei Ling

AU - Chen, Chia Chieh

PY - 2007/8

Y1 - 2007/8

N2 - Imaging serotonin transporters during antidepressant treatment in small animals is a useful tool for preclinical study during drug development. In this work, we aimed to demonstrate the feasibility of using I-ADAM and small-animal SPECT to monitor serotonin transporter availabilities in rat brains prior to and after administration of a selective serotonin re-uptake inhibitor.

AB - Imaging serotonin transporters during antidepressant treatment in small animals is a useful tool for preclinical study during drug development. In this work, we aimed to demonstrate the feasibility of using I-ADAM and small-animal SPECT to monitor serotonin transporter availabilities in rat brains prior to and after administration of a selective serotonin re-uptake inhibitor.

KW - Serotonin transporter

KW - Small-animal SPECT

UR - https://www.scopus.com/pages/publications/34447563770

U2 - 10.1097/MNM.0b013e32825a67cb

DO - 10.1097/MNM.0b013e32825a67cb

M3 - 文章

C2 - 17625383

AN - SCOPUS:34447563770

SN - 0143-3636

VL - 28

SP - 615

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JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

IS - 8

ER -

Imaging the availability of serotonin transporter in rat brain with I-ADAM and small-animal SPECT

Abstract

Keywords

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