Abstract
Adhesion-GPCRs are unusual, owing to their unique structure, comprising a large and complex extracellular domain composed of various common protein modules. Adhesion-GPCR family members are expressed ubiquitously; however the expression of each receptor is highly regulated and often restricted to specific cell types. The EGF-TM7 adhesion-GPCR subfamily members are predominantly expressed by leukocytes and involved in coordinating both the innate and acquired immune responses. Here we highlight some immunological insights in relation to EGF-TM7 proteins and other members of the adhesion-GPCR family.
| Original language | American English |
|---|---|
| Pages (from-to) | 121-127 |
| Journal | Advances in Experimental Medicine and Biology |
| Volume | 706 |
| State | Published - 2010 |
Keywords
- CELL SUBSET
- CHONDROITIN SULFATE
- EGF-TM7 RECEPTOR CD97
- EMR2
- EXPRESSION
- HOST-DEFENSE
- LIGAND CD55
- MACROPHAGE
- RHEUMATOID SYNOVIAL TISSUE
- T-CELLS