Immunohistochemical analysis of dermal mononuclear cell infiltrates in cutaneous lupus erythematosus, polymorphous light eruption, lymphocytic infiltration of Jessner, and cutaneous lymphoid hyperplasia: A comparative differential study

Cutaneous lupus erythematosus (LE), polymorphous light‐eruption (PMLE), lymphocytic infiltration of Jessner (LIJ), and cutaneous lymphoid hyperplasia (CLH) are often difficult to differentiate from ok‐ another by light microscopic examination. We conducted an immunohistochemical analysis of the mononuclear cell infiltrates in 13 LE, 12 PMLE, 10 LIJ, and 13 CLH with various antibodies. Antibodies L26, UCHL1, and S100 achieved statistically significant differences among the lour diseases, but because of the overlaps in the number of UCHL1 (+) T cells and S100 protein (+) cells in individual cases, these two antibodies were not useful. Only (11,11 could be distinguished from LE, PMLE, and LIJ by a greater number of CD20(+) B cells. The latter three' conditions could not be differentiated. Contrary to previous reports, plasmacyloid‐monocytes were not found to be increased in LIJ for the differentiation of the latter from LE and PMLE. Our results support the conclusion that CLH is a reactive lymphoid hyperplastic process with proliferation of both ft and T cells, whereas the T cell was the predominant cell type in the infiltrates of LE, PMLE, and LIJ, indicating that they were related to T cell disorders. The histiocyte was only a minor component cell. The plasmacytoid monocyle in general was not significantly present in all four conditions, but relatively more plasmacytoid monocytes were present in CLH.