Immunological classification of T-cell acute lymphoblastic leukaemia using monoclonal antibodies

Po Min Chen*, Hung Chiang, Chen Kung Chou, Tien Szu Hwang, Benjamin N. Chiang, Melvyn F. Greaves

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

11 Scopus citations

Abstract

We had been able to classify 70 cases of acute lymphoblastic leukaemia (ALL) into different immunological subtypes based on surface marker analysis with the aid of a panel of monoclonal antibodies. The relative proportions of different ALL subclasses appears to be similar to those reported from Europe and the U.S.A. Our results also indicated that monoclonal antibodies OKT11, UCHT-2 and WT1 were very useful in defining pre-T or early T subtypes of ALL. The latter leukaemias lack most maturation-linked T-cell markers but share with the other T-ALL the characteristic of low density or undetectable insulin receptors.

Original languageEnglish
Pages (from-to)339-348
Number of pages10
JournalLeukemia Research
Volume7
Issue number3
DOIs
StatePublished - 1983
Externally publishedYes

Keywords

  • Monoclonal antibody
  • acute lymphoblastic leukaemia
  • differentiation
  • immunodiagnosis

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