Impact of acute hepatitis B virus superinfection on chronic hepatitis C virus imfection

Yun Fan Liaw*, Chau Ting Yeh, Sun Lung Tsai

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

92 Scopus citations


Hepatitis B virus (HBV) and hepatitis C virus (HCV) dual infection is not uncommon, but the impact of acute HBV superinfection in patients with chronic HCV infection is still unknown. Two patients with well documented chronic HCV infection were hospitalized for acute hepatitis, which was serologically confirmed to be acute HBV superinfection. One patient who was seropositive for both HBV-DNA and HCV-RNA upon admission died of hepatic failure. The other became seronegative for HCV-RNA and recovered with alanine aminotransferase normalization, seroclearance of HBsAg, and antibodies to HCV. These findings confirm that acute superinfection in patients with chronic hepatitis may increase the risk for severe hepatitis, and suggest that HBV as the newcomer may suppress the pre-existing HCV. Together with the earlier observation that acute HCV superinfection suppresses pre-existing HBV, it seems that the timing or sequence of infection is a factor influencing the outcome of viral interactions. (C) 2000 by Am. Coll. of Gastroenterology.

Original languageEnglish
Pages (from-to)2978-2980
Number of pages3
JournalAmerican Journal of Gastroenterology
Issue number10
StatePublished - 2000


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