Impact of Apolipoprotein B on Hepatosteatosis in a Population Infected with Hepatitis C Virus: A Cross-Sectional Observational Study

Ming Shyan Lin, Su Er Guo, Huang Shen Lin, Jen-Te Hsu, Yu Sheng Lin, Tsai Hui Lin, Tung Jung Huang, Mei Yen Chen, Chang Min Chung

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations

Abstract

Objective: Non-alcoholic fatty liver disease (NAFLD) is an established risk factor for diabetes, cardiovascular disease, antiviral treatment resistance, and progression of chronic hepatitis C virus (HCV) infection to fibrosis. Apolipoprotein-B 100 (ApoB-100) is a dyslipidemia marker and steatosis predictor. We assess the correlation between ApoB-100 and hepatosteatosis. Methods: This cross-sectional study enrolled 1,218 HCV-seropositive participants from a 2012-2013 health checkup in Taiwan. NAFLD was detected using ultrasound. All anthropometric and laboratory studies that included ApoB-100 were evaluated whether or not ApoB-100 predicts NAFLD. Logistic regression was also used to examine the association between ApoB-100 and NAFLD. Results: Participants were 47.16 ± 16.08 years old (mean age). The overall prevalence of NAFLD was 35.8% (n = 436; 32.8% men, 38.1% women). Participants with ApoB-100 ≥ 8 had a significantly higher incidence of NAFLD (39.4 vs. 29.4%; 95% CI 0.044-0.156; p < 0.001). After confounding factors had been adjusted for, ApoB-100 was significantly associated with NAFLD (OR 5.45; 95% CI 1.64-18.06; p = 0.006) and high-grade hepatosteatosis (OR 7.73; 95% CI 1.74-34.35; p = 0.007). Conclusion: ApoB-100 is strongly associated with NAFLD in people with non-genotype 3 HCV; greater ApoB-100 content is significantly correlated with higher-grade hepatosteatosis.

Original languageEnglish
Pages (from-to)101-111
Number of pages11
JournalObesity Facts
Volume9
Issue number2
DOIs
StatePublished - 01 05 2016

Bibliographical note

Publisher Copyright:
© 2016 The Author(s) Published by S. Karger GmbH, Freiburg.

Keywords

  • Apolipoprotein-B
  • Hepatitis C virus
  • Non-alcoholic fatty liver disease

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