Impact of BRCA mutation on the survival and risk of contralateral breast cancer in Asian breast cancer patients

Po Han Lin; Shin Cheh Chen; Ling Ming Tseng; King Jen Chang; Ai Chu Huang; Kuo Chih Cheng; Karen Yang; Hui Chen Wu; Tsu Yi Chao; Yuan Ching Chang; Peng Chan Lin; Wen Hung Kuo; Wen Lin Kuo; Ching Hung Lin; Huo Mu Chen; Dah Cherng Yeh; Liang Chih Liu; Chun Yu Liu; Ming Yang Wang; Chiao Lo; Yen Shen Lu; Chiun Sheng Huang

doi:10.1007/s10549-021-06446-7

Impact of BRCA mutation on the survival and risk of contralateral breast cancer in Asian breast cancer patients

Po Han Lin, Shin Cheh Chen, Ling Ming Tseng, King Jen Chang, Ai Chu Huang, Kuo Chih Cheng, Karen Yang, Hui Chen Wu, Tsu Yi Chao, Yuan Ching Chang, Peng Chan Lin, Wen Hung Kuo, Wen Lin Kuo, Ching Hung Lin, Huo Mu Chen, Dah Cherng Yeh, Liang Chih Liu, Chun Yu Liu, Ming Yang Wang, Chiao LoYen Shen Lu, Chiun Sheng Huang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

Purpose: Breast cancer is increasing around the globe, including Asia. We aimed to examine the survival and risk of contralateral breast cancer (CBC) in Asian breast cancer patients with BRCA mutations. Methods: A total of 128 breast cancer patients with germline BRCA mutations and 4,754 control breast cancer patients were enrolled. Data on clinical–pathologic characteristics, survival, and CBC were collected from the medical record. The rates of survival and CBC were estimated by Kaplan–Meier method. Results: The mean age of onset in BRCA mutation carriers was significantly younger than control patients (BRCA vs. Non-BRCA: 43.9 vs. 53.2 years old). BRCA mutation carriers had a higher proportion of triple-negative breast cancer (TNBC) (52%) than control patients (12%, p < 0.001). The risk of CBC was significantly higher in BRCA mutation patients than in control cases (hazard ratio (HR) = 3.95, 95% CI 2.71–5.75); when stratified by genotype, the HRs (95%CI) were 4.84 (3.00–7.82) for BRCA1 and 3.13 (1.78–5.49) for BRCA2 carriers, respectively. Moreover, BRCA1 mutation patients with triple-negative breast cancer (TNBC) as their first breast cancer had the highest risk of CBC (HR = 5.55, 95% CI 3.29–9.34). However, we did not observe any differences in relapse-free survival and overall survival between mutation carriers and control patients. Conclusion: Our study suggest that BRCA patients had a significantly higher risk of developing CBC, particularly for BRCA1 mutation carriers with TNBC as the first breast cancer.

Original language	English
Pages (from-to)	629-637
Number of pages	9
Journal	Breast Cancer Research and Treatment
Volume	192
Issue number	3
DOIs	https://doi.org/10.1007/s10549-021-06446-7
State	Published - 04 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

Asian women
BRCA1
BRCA2
Contralateral breast cancer
Survival

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10549-021-06446-7

Cite this

Lin, P. H., Chen, S. C., Tseng, L. M., Chang, K. J., Huang, A. C., Cheng, K. C., Yang, K., Wu, H. C., Chao, T. Y., Chang, Y. C., Lin, P. C., Kuo, W. H., Kuo, W. L., Lin, C. H., Chen, H. M., Yeh, D. C., Liu, L. C., Liu, C. Y., Wang, M. Y., ... Huang, C. S. (2022). Impact of BRCA mutation on the survival and risk of contralateral breast cancer in Asian breast cancer patients. Breast Cancer Research and Treatment, 192(3), 629-637. https://doi.org/10.1007/s10549-021-06446-7

@article{94b0b92b4d26406c9af336f72695b011,

title = "Impact of BRCA mutation on the survival and risk of contralateral breast cancer in Asian breast cancer patients",

abstract = "Purpose: Breast cancer is increasing around the globe, including Asia. We aimed to examine the survival and risk of contralateral breast cancer (CBC) in Asian breast cancer patients with BRCA mutations. Methods: A total of 128 breast cancer patients with germline BRCA mutations and 4,754 control breast cancer patients were enrolled. Data on clinical–pathologic characteristics, survival, and CBC were collected from the medical record. The rates of survival and CBC were estimated by Kaplan–Meier method. Results: The mean age of onset in BRCA mutation carriers was significantly younger than control patients (BRCA vs. Non-BRCA: 43.9 vs. 53.2 years old). BRCA mutation carriers had a higher proportion of triple-negative breast cancer (TNBC) (52%) than control patients (12%, p < 0.001). The risk of CBC was significantly higher in BRCA mutation patients than in control cases (hazard ratio (HR) = 3.95, 95% CI 2.71–5.75); when stratified by genotype, the HRs (95%CI) were 4.84 (3.00–7.82) for BRCA1 and 3.13 (1.78–5.49) for BRCA2 carriers, respectively. Moreover, BRCA1 mutation patients with triple-negative breast cancer (TNBC) as their first breast cancer had the highest risk of CBC (HR = 5.55, 95% CI 3.29–9.34). However, we did not observe any differences in relapse-free survival and overall survival between mutation carriers and control patients. Conclusion: Our study suggest that BRCA patients had a significantly higher risk of developing CBC, particularly for BRCA1 mutation carriers with TNBC as the first breast cancer.",

keywords = "Asian women, BRCA1, BRCA2, Contralateral breast cancer, Survival",

author = "Lin, {Po Han} and Chen, {Shin Cheh} and Tseng, {Ling Ming} and Chang, {King Jen} and Huang, {Ai Chu} and Cheng, {Kuo Chih} and Karen Yang and Wu, {Hui Chen} and Chao, {Tsu Yi} and Chang, {Yuan Ching} and Lin, {Peng Chan} and Kuo, {Wen Hung} and Kuo, {Wen Lin} and Lin, {Ching Hung} and Chen, {Huo Mu} and Yeh, {Dah Cherng} and Liu, {Liang Chih} and Liu, {Chun Yu} and Wang, {Ming Yang} and Chiao Lo and Lu, {Yen Shen} and Huang, {Chiun Sheng}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2022",

month = apr,

doi = "10.1007/s10549-021-06446-7",

language = "英语",

volume = "192",

pages = "629--637",

journal = "Breast Cancer Research and Treatment",

issn = "0167-6806",

publisher = "Springer",

number = "3",

}

Lin, PH, Chen, SC, Tseng, LM, Chang, KJ, Huang, AC, Cheng, KC, Yang, K, Wu, HC, Chao, TY, Chang, YC, Lin, PC, Kuo, WH, Kuo, WL, Lin, CH, Chen, HM, Yeh, DC, Liu, LC, Liu, CY, Wang, MY, Lo, C, Lu, YS & Huang, CS 2022, 'Impact of BRCA mutation on the survival and risk of contralateral breast cancer in Asian breast cancer patients', Breast Cancer Research and Treatment, vol. 192, no. 3, pp. 629-637. https://doi.org/10.1007/s10549-021-06446-7

TY - JOUR

T1 - Impact of BRCA mutation on the survival and risk of contralateral breast cancer in Asian breast cancer patients

AU - Lin, Po Han

AU - Chen, Shin Cheh

AU - Tseng, Ling Ming

AU - Chang, King Jen

AU - Huang, Ai Chu

AU - Cheng, Kuo Chih

AU - Yang, Karen

AU - Wu, Hui Chen

AU - Chao, Tsu Yi

AU - Chang, Yuan Ching

AU - Lin, Peng Chan

AU - Kuo, Wen Hung

AU - Kuo, Wen Lin

AU - Lin, Ching Hung

AU - Chen, Huo Mu

AU - Yeh, Dah Cherng

AU - Liu, Liang Chih

AU - Liu, Chun Yu

AU - Wang, Ming Yang

AU - Lo, Chiao

AU - Lu, Yen Shen

AU - Huang, Chiun Sheng

PY - 2022/4

Y1 - 2022/4

N2 - Purpose: Breast cancer is increasing around the globe, including Asia. We aimed to examine the survival and risk of contralateral breast cancer (CBC) in Asian breast cancer patients with BRCA mutations. Methods: A total of 128 breast cancer patients with germline BRCA mutations and 4,754 control breast cancer patients were enrolled. Data on clinical–pathologic characteristics, survival, and CBC were collected from the medical record. The rates of survival and CBC were estimated by Kaplan–Meier method. Results: The mean age of onset in BRCA mutation carriers was significantly younger than control patients (BRCA vs. Non-BRCA: 43.9 vs. 53.2 years old). BRCA mutation carriers had a higher proportion of triple-negative breast cancer (TNBC) (52%) than control patients (12%, p < 0.001). The risk of CBC was significantly higher in BRCA mutation patients than in control cases (hazard ratio (HR) = 3.95, 95% CI 2.71–5.75); when stratified by genotype, the HRs (95%CI) were 4.84 (3.00–7.82) for BRCA1 and 3.13 (1.78–5.49) for BRCA2 carriers, respectively. Moreover, BRCA1 mutation patients with triple-negative breast cancer (TNBC) as their first breast cancer had the highest risk of CBC (HR = 5.55, 95% CI 3.29–9.34). However, we did not observe any differences in relapse-free survival and overall survival between mutation carriers and control patients. Conclusion: Our study suggest that BRCA patients had a significantly higher risk of developing CBC, particularly for BRCA1 mutation carriers with TNBC as the first breast cancer.

AB - Purpose: Breast cancer is increasing around the globe, including Asia. We aimed to examine the survival and risk of contralateral breast cancer (CBC) in Asian breast cancer patients with BRCA mutations. Methods: A total of 128 breast cancer patients with germline BRCA mutations and 4,754 control breast cancer patients were enrolled. Data on clinical–pathologic characteristics, survival, and CBC were collected from the medical record. The rates of survival and CBC were estimated by Kaplan–Meier method. Results: The mean age of onset in BRCA mutation carriers was significantly younger than control patients (BRCA vs. Non-BRCA: 43.9 vs. 53.2 years old). BRCA mutation carriers had a higher proportion of triple-negative breast cancer (TNBC) (52%) than control patients (12%, p < 0.001). The risk of CBC was significantly higher in BRCA mutation patients than in control cases (hazard ratio (HR) = 3.95, 95% CI 2.71–5.75); when stratified by genotype, the HRs (95%CI) were 4.84 (3.00–7.82) for BRCA1 and 3.13 (1.78–5.49) for BRCA2 carriers, respectively. Moreover, BRCA1 mutation patients with triple-negative breast cancer (TNBC) as their first breast cancer had the highest risk of CBC (HR = 5.55, 95% CI 3.29–9.34). However, we did not observe any differences in relapse-free survival and overall survival between mutation carriers and control patients. Conclusion: Our study suggest that BRCA patients had a significantly higher risk of developing CBC, particularly for BRCA1 mutation carriers with TNBC as the first breast cancer.

KW - Asian women

KW - BRCA1

KW - BRCA2

KW - Contralateral breast cancer

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=85124202210&partnerID=8YFLogxK

U2 - 10.1007/s10549-021-06446-7

DO - 10.1007/s10549-021-06446-7

M3 - 文章

C2 - 35113257

AN - SCOPUS:85124202210

SN - 0167-6806

VL - 192

SP - 629

EP - 637

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

IS - 3

ER -

Impact of BRCA mutation on the survival and risk of contralateral breast cancer in Asian breast cancer patients

Abstract

Bibliographical note

Keywords

UN SDGs

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