Impact of cholesterol on disease progression

Chun Jung Lin, Cheng Kuo Lai, Min Chuan Kao, Lii Tzu Wu, U. Ging Lo, Li Chiung Lin, Yu An Chen, Ho Lin, Jer Tsong Hsieh, Chih Ho Lai, Chia Der Lin*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

27 Scopus citations

Abstract

Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lipids can be dissociated, and this renders the cell structure nonfunctional and therefore mitigates disease severity. This review focuses on the role of cholesterol in disease progression including cancer development and infectious diseases. Understanding the molecular mechanisms of cholesterol in these diseases may provide insight into the development of novel strategies for controlling these diseases in clinical scenarios.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalBioMedicine (Netherlands)
Volume5
Issue number2
DOIs
StatePublished - 01 06 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© Author(s) 2015.

Keywords

  • Cancer development
  • Cholesterol
  • HMG-CoA reductase
  • Infectious disease
  • Lipid rafts

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