Impact of cholesterol on disease progression

Chun Jung Lin; Cheng Kuo Lai; Min Chuan Kao; Lii Tzu Wu; U. Ging Lo; Li Chiung Lin; Yu An Chen; Ho Lin; Jer Tsong Hsieh; Chih Ho Lai; Chia Der Lin

doi:10.7603/s40681-015-0007-8

Impact of cholesterol on disease progression

Chun Jung Lin, Cheng Kuo Lai, Min Chuan Kao, Lii Tzu Wu, U. Ging Lo, Li Chiung Lin, Yu An Chen, Ho Lin, Jer Tsong Hsieh, Chih Ho Lai, Chia Der Lin^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

28 Scopus citations

Abstract

Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lipids can be dissociated, and this renders the cell structure nonfunctional and therefore mitigates disease severity. This review focuses on the role of cholesterol in disease progression including cancer development and infectious diseases. Understanding the molecular mechanisms of cholesterol in these diseases may provide insight into the development of novel strategies for controlling these diseases in clinical scenarios.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	BioMedicine (Netherlands)
Volume	5
Issue number	2
DOIs	https://doi.org/10.7603/s40681-015-0007-8
State	Published - 01 06 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© Author(s) 2015.

Keywords

Cancer development
Cholesterol
HMG-CoA reductase
Infectious disease
Lipid rafts

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7603/s40681-015-0007-8

Cite this

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title = "Impact of cholesterol on disease progression",

abstract = "Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lipids can be dissociated, and this renders the cell structure nonfunctional and therefore mitigates disease severity. This review focuses on the role of cholesterol in disease progression including cancer development and infectious diseases. Understanding the molecular mechanisms of cholesterol in these diseases may provide insight into the development of novel strategies for controlling these diseases in clinical scenarios.",

keywords = "Cancer development, Cholesterol, HMG-CoA reductase, Infectious disease, Lipid rafts",

author = "Lin, {Chun Jung} and Lai, {Cheng Kuo} and Kao, {Min Chuan} and Wu, {Lii Tzu} and Lo, {U. Ging} and Lin, {Li Chiung} and Chen, {Yu An} and Ho Lin and Hsieh, {Jer Tsong} and Lai, {Chih Ho} and Lin, {Chia Der}",

note = "Publisher Copyright: {\textcopyright} Author(s) 2015.",

year = "2015",

month = jun,

day = "1",

doi = "10.7603/s40681-015-0007-8",

language = "英语",

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T1 - Impact of cholesterol on disease progression

AU - Lin, Chun Jung

AU - Lai, Cheng Kuo

AU - Kao, Min Chuan

AU - Wu, Lii Tzu

AU - Lo, U. Ging

AU - Lin, Li Chiung

AU - Chen, Yu An

AU - Lin, Ho

AU - Hsieh, Jer Tsong

AU - Lai, Chih Ho

AU - Lin, Chia Der

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lipids can be dissociated, and this renders the cell structure nonfunctional and therefore mitigates disease severity. This review focuses on the role of cholesterol in disease progression including cancer development and infectious diseases. Understanding the molecular mechanisms of cholesterol in these diseases may provide insight into the development of novel strategies for controlling these diseases in clinical scenarios.

AB - Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lipids can be dissociated, and this renders the cell structure nonfunctional and therefore mitigates disease severity. This review focuses on the role of cholesterol in disease progression including cancer development and infectious diseases. Understanding the molecular mechanisms of cholesterol in these diseases may provide insight into the development of novel strategies for controlling these diseases in clinical scenarios.

KW - Cancer development

KW - Cholesterol

KW - HMG-CoA reductase

KW - Infectious disease

KW - Lipid rafts

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DO - 10.7603/s40681-015-0007-8

M3 - 文章

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JO - BioMedicine (Netherlands)

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ER -

Impact of cholesterol on disease progression

Abstract

Bibliographical note

Keywords

UN SDGs

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