Impact of hyperglycemic control on left ventricular myocardium: A molecular and cellular basic study in a diabetic rat model

Pei Hsun Sung; Cheuk Kwan Sun; Sheung Fat Ko; Li Teh Chang; Jiunn Jye Sheu; Fan Yen Lee; Chiung Jen Wu; Sarah Chua; Hon Kan Yip

doi:10.1536/ihj.50.191

Impact of hyperglycemic control on left ventricular myocardium: A molecular and cellular basic study in a diabetic rat model

Pei Hsun Sung, Cheuk Kwan Sun, Sheung Fat Ko, Li Teh Chang, Jiunn Jye Sheu, Fan Yen Lee, Chiung Jen Wu, Sarah Chua, Hon Kan Yip^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

10 Scopus citations

Abstract

This experimental study investigated the impact of hyperglycemic control on left ventricular (LV) function using a model of diabetes mellitus (DM) (induced by streptozocin 60 mg/kg). Sixteen adult-Sprague Dawley rats were divided into group 1 (poor hyperglycemic control, n = 8) and group 2 (good hyperglycemic control, n = 8). Diabetic rats and 8 healthy rats serving as controls (group 3) were sacrificed on day 28 after DM induction. The results demonstrated that HbA1C on day 28 was higher in group 1 than in groups 2 and 3 (P < 0.0001). The mRNA expressions of MMP-9 and endothelin-1 were elevated in group 1 compared with that in groups 2 and 3 (P < 0.05), whereas PGC-1α and eNOS were lower in group 1 than in groups 2 and 3 (P < 0.05). The number of apoptotic nuclei was higher in group 1 than in groups 2 and 3 (P < 0.01). The integrated area (μm2) of connexin43 (Cx43), Cx43 protein expression, and LV function were lower in group 1 than in groups 2 and 3 (P < 0.05). Moreover, PKC-ε expression in the mitochondrial compartment was decreased in group 1 compared to that in groups 2 and 3 (P < 0.005).

Original language	English
Pages (from-to)	191-206
Number of pages	16
Journal	International Heart Journal
Volume	50
Issue number	2
DOIs	https://doi.org/10.1536/ihj.50.191
State	Published - 2009
Externally published	Yes

Keywords

Hyperglycemia
Inflammation
Left ventricular dysfunction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1536/ihj.50.191

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title = "Impact of hyperglycemic control on left ventricular myocardium: A molecular and cellular basic study in a diabetic rat model",

abstract = "This experimental study investigated the impact of hyperglycemic control on left ventricular (LV) function using a model of diabetes mellitus (DM) (induced by streptozocin 60 mg/kg). Sixteen adult-Sprague Dawley rats were divided into group 1 (poor hyperglycemic control, n = 8) and group 2 (good hyperglycemic control, n = 8). Diabetic rats and 8 healthy rats serving as controls (group 3) were sacrificed on day 28 after DM induction. The results demonstrated that HbA1C on day 28 was higher in group 1 than in groups 2 and 3 (P < 0.0001). The mRNA expressions of MMP-9 and endothelin-1 were elevated in group 1 compared with that in groups 2 and 3 (P < 0.05), whereas PGC-1α and eNOS were lower in group 1 than in groups 2 and 3 (P < 0.05). The number of apoptotic nuclei was higher in group 1 than in groups 2 and 3 (P < 0.01). The integrated area (μm2) of connexin43 (Cx43), Cx43 protein expression, and LV function were lower in group 1 than in groups 2 and 3 (P < 0.05). Moreover, PKC-ε expression in the mitochondrial compartment was decreased in group 1 compared to that in groups 2 and 3 (P < 0.005).",

keywords = "Hyperglycemia, Inflammation, Left ventricular dysfunction",

author = "Sung, {Pei Hsun} and Sun, {Cheuk Kwan} and Ko, {Sheung Fat} and Chang, {Li Teh} and Sheu, {Jiunn Jye} and Lee, {Fan Yen} and Wu, {Chiung Jen} and Sarah Chua and Yip, {Hon Kan}",

year = "2009",

doi = "10.1536/ihj.50.191",

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T2 - A molecular and cellular basic study in a diabetic rat model

AU - Sung, Pei Hsun

AU - Sun, Cheuk Kwan

AU - Ko, Sheung Fat

AU - Chang, Li Teh

AU - Sheu, Jiunn Jye

AU - Lee, Fan Yen

AU - Wu, Chiung Jen

AU - Chua, Sarah

AU - Yip, Hon Kan

PY - 2009

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N2 - This experimental study investigated the impact of hyperglycemic control on left ventricular (LV) function using a model of diabetes mellitus (DM) (induced by streptozocin 60 mg/kg). Sixteen adult-Sprague Dawley rats were divided into group 1 (poor hyperglycemic control, n = 8) and group 2 (good hyperglycemic control, n = 8). Diabetic rats and 8 healthy rats serving as controls (group 3) were sacrificed on day 28 after DM induction. The results demonstrated that HbA1C on day 28 was higher in group 1 than in groups 2 and 3 (P < 0.0001). The mRNA expressions of MMP-9 and endothelin-1 were elevated in group 1 compared with that in groups 2 and 3 (P < 0.05), whereas PGC-1α and eNOS were lower in group 1 than in groups 2 and 3 (P < 0.05). The number of apoptotic nuclei was higher in group 1 than in groups 2 and 3 (P < 0.01). The integrated area (μm2) of connexin43 (Cx43), Cx43 protein expression, and LV function were lower in group 1 than in groups 2 and 3 (P < 0.05). Moreover, PKC-ε expression in the mitochondrial compartment was decreased in group 1 compared to that in groups 2 and 3 (P < 0.005).

AB - This experimental study investigated the impact of hyperglycemic control on left ventricular (LV) function using a model of diabetes mellitus (DM) (induced by streptozocin 60 mg/kg). Sixteen adult-Sprague Dawley rats were divided into group 1 (poor hyperglycemic control, n = 8) and group 2 (good hyperglycemic control, n = 8). Diabetic rats and 8 healthy rats serving as controls (group 3) were sacrificed on day 28 after DM induction. The results demonstrated that HbA1C on day 28 was higher in group 1 than in groups 2 and 3 (P < 0.0001). The mRNA expressions of MMP-9 and endothelin-1 were elevated in group 1 compared with that in groups 2 and 3 (P < 0.05), whereas PGC-1α and eNOS were lower in group 1 than in groups 2 and 3 (P < 0.05). The number of apoptotic nuclei was higher in group 1 than in groups 2 and 3 (P < 0.01). The integrated area (μm2) of connexin43 (Cx43), Cx43 protein expression, and LV function were lower in group 1 than in groups 2 and 3 (P < 0.05). Moreover, PKC-ε expression in the mitochondrial compartment was decreased in group 1 compared to that in groups 2 and 3 (P < 0.005).

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KW - Inflammation

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Impact of hyperglycemic control on left ventricular myocardium: A molecular and cellular basic study in a diabetic rat model

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Keywords

UN SDGs

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