Impact of renal dysfunction on surgical outcomes in patients with aortic dissection

Pei Yi Fan, Chao Yu Chen, Cheng Chia Lee, Kuo Sheng Liu, Victor Chien Chia Wu, Pei Chun Fan, Ming Yang Chang, Jason Chih Hsiang Chang, Ya Chung Tian, Shao Wei Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

7 Scopus citations


Preoperative renal dysfunction is associated with mortality in patients who undergo coronary artery bypass graft and valve surgery. However, the role of preoperative renal dysfunction in type A aortic dissection (TAAD) remains unclear. This study aimed to evaluate the impact of preoperative renal dysfunction on the outcome of surgical intervention in patients with TAAD. We retrospectively studied the outcomes of 159 patients with TAAD who were treated at a tertiary referral hospital between 2005 and 2010. The demographics and surgical details of patients were analyzed according to their renal function. Risk factors for outcomes were analyzed using multivariable logistic regression. Thirty-two of the patients (20.1%) had preoperative serum creatinine of 1.5mg/dL or more. The multivariable logistic regression model revealed independent risk factors of in-hospital mortality to be renal dysfunction (odds ratio [OR], 3.79; 95% confidence interval [CI], 1.64-8.77), preoperative shock (OR, 8.75; 95% CI, 2.83-27.02), and bypass time (OR, 1.008; 95% CI, 1.003-1.013). In addition, patients with renal dysfunction exhibited a lower 90-day survival rate than did patients without the condition (P of log-rank test=.005). Preoperative renal dysfunction may have a critical role in the surgical outcomes of patients with TAAD. Additional large-scale investigations are warranted.

Original languageEnglish
Article numbere15453
JournalMedicine (United States)
Issue number20
StatePublished - 01 05 2019

Bibliographical note

Publisher Copyright:
© 2019 the Author(s).


  • prognosis
  • renal dysfunction
  • risk factors
  • type A aortic dissection (TAAD)


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