Impact of the gut microbiota, prebiotics, and probiotics on human health and disease

Chuan Sheng Lin; Chih Jung Chang; Chia Chen Lu; Jan Martel; David M. Ojcius; Yun Fei Ko; John D. Young; Hsin Chih Lai

doi:10.4103/2319-4170.138314

Impact of the gut microbiota, prebiotics, and probiotics on human health and disease

Chuan Sheng Lin
, Chih Jung Chang
, Chia Chen Lu
, Jan Martel
, David M. Ojcius
, Yun Fei Ko
, John D. Young
, Hsin Chih Lai^*

^*Corresponding author for this work

Chang Gung University
Fu Jen Catholic University
University of California Merced
Chang Gung Biotechnology Corporation
Ming Chi University of Technology

Research output: Contribution to journal › Review article › peer-review

136 Scopus citations

Abstract

Recent studies have revealed that the gut microbiota regulates many physiological functions, ranging from energy regulation and cognitive processes to toxin neutralization and immunity against pathogens. Accordingly, alterations in the composition of the gut microbiota have been shown to contribute to the development of various chronic diseases. The main objectives of this review are to present recent breakthroughs in the study of the gut microbiota and show that intestinal bacteria play a critical role in the development of different disease conditions, including obesity, fatty liver disease, and lung infection. We also highlight the potential application of prebiotics and probiotics in maintaining optimal health and treating chronic inflammatory and immunity-related diseases.

Original language	English
Pages (from-to)	259-268
Number of pages	10
Journal	Biomedical Journal
Volume	37
Issue number	5
DOIs	https://doi.org/10.4103/2319-4170.138314
State	Published - 01 09 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

disease
gut microflora
immunity
prebiotics
probiotics

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10.4103/2319-4170.138314

Cite this

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title = "Impact of the gut microbiota, prebiotics, and probiotics on human health and disease",

abstract = "Recent studies have revealed that the gut microbiota regulates many physiological functions, ranging from energy regulation and cognitive processes to toxin neutralization and immunity against pathogens. Accordingly, alterations in the composition of the gut microbiota have been shown to contribute to the development of various chronic diseases. The main objectives of this review are to present recent breakthroughs in the study of the gut microbiota and show that intestinal bacteria play a critical role in the development of different disease conditions, including obesity, fatty liver disease, and lung infection. We also highlight the potential application of prebiotics and probiotics in maintaining optimal health and treating chronic inflammatory and immunity-related diseases.",

keywords = "disease, gut microflora, immunity, prebiotics, probiotics",

author = "Lin, \{Chuan Sheng\} and Chang, \{Chih Jung\} and Lu, \{Chia Chen\} and Jan Martel and Ojcius, \{David M.\} and Ko, \{Yun Fei\} and Young, \{John D.\} and Lai, \{Hsin Chih\}",

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T1 - Impact of the gut microbiota, prebiotics, and probiotics on human health and disease

AU - Lin, Chuan Sheng

AU - Chang, Chih Jung

AU - Lu, Chia Chen

AU - Martel, Jan

AU - Ojcius, David M.

AU - Ko, Yun Fei

AU - Young, John D.

AU - Lai, Hsin Chih

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Recent studies have revealed that the gut microbiota regulates many physiological functions, ranging from energy regulation and cognitive processes to toxin neutralization and immunity against pathogens. Accordingly, alterations in the composition of the gut microbiota have been shown to contribute to the development of various chronic diseases. The main objectives of this review are to present recent breakthroughs in the study of the gut microbiota and show that intestinal bacteria play a critical role in the development of different disease conditions, including obesity, fatty liver disease, and lung infection. We also highlight the potential application of prebiotics and probiotics in maintaining optimal health and treating chronic inflammatory and immunity-related diseases.

AB - Recent studies have revealed that the gut microbiota regulates many physiological functions, ranging from energy regulation and cognitive processes to toxin neutralization and immunity against pathogens. Accordingly, alterations in the composition of the gut microbiota have been shown to contribute to the development of various chronic diseases. The main objectives of this review are to present recent breakthroughs in the study of the gut microbiota and show that intestinal bacteria play a critical role in the development of different disease conditions, including obesity, fatty liver disease, and lung infection. We also highlight the potential application of prebiotics and probiotics in maintaining optimal health and treating chronic inflammatory and immunity-related diseases.

KW - disease

KW - gut microflora

KW - immunity

KW - prebiotics

KW - probiotics

UR - https://www.scopus.com/pages/publications/84908650241

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DO - 10.4103/2319-4170.138314

M3 - 文献综述

C2 - 25179725

AN - SCOPUS:84908650241

SN - 2319-4170

VL - 37

SP - 259

EP - 268

JO - Biomedical Journal

JF - Biomedical Journal

IS - 5

ER -

Impact of the gut microbiota, prebiotics, and probiotics on human health and disease

Abstract

UN SDGs

Keywords

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