Impact of the material composition on proton range variation - A Monte Carlo study

S. W. Wu, C. J. Tung, C. C. Lee, K. H. Fan, H. C. Huang, T. C. Chao*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

3 Scopus citations


In this study, we used the Geant4 toolkit to demonstrate the impacts of the material composition of tissues on proton range variation. Bragg curves of different materials subjected to a 250MeV mono-energy proton beam were simulated and compared. These simulated materials included adipose, heart, brain, cartilage, cortical bone and water. The results showed that there was significant proton range deviation between Bragg curves, especially for cortical bone. The R50 values for a 250MeV proton beam were approximately 39.55cm, 35.52cm, 37.00cm, 36.51cm, 36.72cm, 22.53cm, and 38.52cm in the phantoms that were composed completely of adipose, cartilage, tissue, heart, brain, cortical bone, and water, respectively. Mass density and electron density were used to scale the proton range for each material; electron density provided better range scaling. In addition, a similar comparison was performed by artificially setting all material density to 1.0g/cm3 to evaluate the range deviation due to chemical components alone. Tissue heterogeneity effects due to density variation were more significant, and less significant for chemical composition variation unless the Z/A was very different.

Original languageEnglish
Pages (from-to)199-202
Number of pages4
JournalRadiation Physics and Chemistry
StatePublished - 01 11 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd.


  • Material composition
  • Monte Carlo
  • Proton therapy
  • Tissue heterogeneity


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