Impact of therapy on the long-term outcome of chronic hepatitis B

Yun Fan Liaw*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Chronic hepatitis B virus (HBV) infection is a dynamic state of interactions between HBV, the hepatocytes, and the patient's immune system. HBV replication is the key driving force for the HBV-related immune clearance events that determine the outcomes. The extended immune clearance phase is associated with liver disease progression, including development of cirrhosis and hepatocellular carcinoma (HCC). Thus, the primary aim of therapy is to eliminate or permanently suppress HBV to reduce hepatitis activity and thereby reduce the risk or slow the progression of liver disease.

Original languageEnglish
Pages (from-to)413-423
Number of pages11
JournalClinics in Liver Disease
Issue number3
StatePublished - 08 2013


  • Cirrhosis
  • Hepatic decompensation
  • Hepatic fibrosis
  • Hepatocellular carcinoma
  • Interferon
  • Nucleos(t)ide analog


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