Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program

William Wang Yu Su; Yi Huah Lee; Amy Ming Fang Yen; Sam Li Sheng Chen; Chen Yang Hsu; Sherry Yueh Hsia Chiu; Jean Ching Yuan Fann; Yi Chia Lee; Han Mo Chiu; Shu Chun Hsiao; Tsui Hsia Hsu; Hsiu Hsi Chen

doi:10.1002/hed.26504

Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program

William Wang Yu Su, Yi Huah Lee, Amy Ming Fang Yen, Sam Li Sheng Chen, Chen Yang Hsu, Sherry Yueh Hsia Chiu, Jean Ching Yuan Fann, Yi Chia Lee, Han Mo Chiu, Shu Chun Hsiao, Tsui Hsia Hsu, Hsiu Hsi Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

11 Scopus citations

Abstract

Background: To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods: We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012. Results: The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01-1.24) and 1.00 (0.91-1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P <.05). However, treatment at medical center had a lower mortality (0.83, 0.75-0.91) than local/regional hospital. Conclusions: Treatment delay longer than 6 weeks for OSCCs detected via a population-based screening program had unfavorable survival.

Original language	English
Pages (from-to)	473-484
Number of pages	12
Journal	Head and Neck
Volume	43
Issue number	2
DOIs	https://doi.org/10.1002/hed.26504
State	Published - 02 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.

Keywords

betel quid chewing
cigarette smoking
oral/oropharyngeal cancer
survival
treatment delay

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.26504

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title = "Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program",

abstract = "Background: To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods: We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012. Results: The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01-1.24) and 1.00 (0.91-1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P <.05). However, treatment at medical center had a lower mortality (0.83, 0.75-0.91) than local/regional hospital. Conclusions: Treatment delay longer than 6 weeks for OSCCs detected via a population-based screening program had unfavorable survival.",

keywords = "betel quid chewing, cigarette smoking, oral/oropharyngeal cancer, survival, treatment delay",

author = "Su, {William Wang Yu} and Lee, {Yi Huah} and Yen, {Amy Ming Fang} and Chen, {Sam Li Sheng} and Hsu, {Chen Yang} and Chiu, {Sherry Yueh Hsia} and Fann, {Jean Ching Yuan} and Lee, {Yi Chia} and Chiu, {Han Mo} and Hsiao, {Shu Chun} and Hsu, {Tsui Hsia} and Chen, {Hsiu Hsi}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.",

year = "2021",

month = feb,

doi = "10.1002/hed.26504",

language = "英语",

volume = "43",

pages = "473--484",

journal = "Head and Neck",

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}

TY - JOUR

T1 - Impact of treatment delay on survival of oral/oropharyngeal cancers

T2 - Results of a nationwide screening program

AU - Su, William Wang Yu

AU - Lee, Yi Huah

AU - Yen, Amy Ming Fang

AU - Chen, Sam Li Sheng

AU - Hsu, Chen Yang

AU - Chiu, Sherry Yueh Hsia

AU - Fann, Jean Ching Yuan

AU - Lee, Yi Chia

AU - Chiu, Han Mo

AU - Hsiao, Shu Chun

AU - Hsu, Tsui Hsia

AU - Chen, Hsiu Hsi

PY - 2021/2

Y1 - 2021/2

N2 - Background: To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods: We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012. Results: The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01-1.24) and 1.00 (0.91-1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P <.05). However, treatment at medical center had a lower mortality (0.83, 0.75-0.91) than local/regional hospital. Conclusions: Treatment delay longer than 6 weeks for OSCCs detected via a population-based screening program had unfavorable survival.

AB - Background: To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods: We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012. Results: The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01-1.24) and 1.00 (0.91-1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P <.05). However, treatment at medical center had a lower mortality (0.83, 0.75-0.91) than local/regional hospital. Conclusions: Treatment delay longer than 6 weeks for OSCCs detected via a population-based screening program had unfavorable survival.

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KW - cigarette smoking

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ER -

Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program

Abstract

Bibliographical note

Keywords

UN SDGs

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