Abstract
Background: To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods: We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012. Results: The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01-1.24) and 1.00 (0.91-1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P <.05). However, treatment at medical center had a lower mortality (0.83, 0.75-0.91) than local/regional hospital. Conclusions: Treatment delay longer than 6 weeks for OSCCs detected via a population-based screening program had unfavorable survival.
Original language | English |
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Pages (from-to) | 473-484 |
Number of pages | 12 |
Journal | Head and Neck |
Volume | 43 |
Issue number | 2 |
DOIs | |
State | Published - 02 2021 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.
Keywords
- betel quid chewing
- cigarette smoking
- oral/oropharyngeal cancer
- survival
- treatment delay