Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program

William Wang Yu Su; Yi Huah Lee; Amy Ming Fang Yen; Sam Li Sheng Chen; Chen Yang Hsu; Sherry Yueh Hsia Chiu; Jean Ching Yuan Fann; Yi Chia Lee; Han Mo Chiu; Shu Chun Hsiao; Tsui Hsia Hsu; Hsiu Hsi Chen

doi:10.1002/hed.26504

Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program

William Wang Yu Su
, Yi Huah Lee
, Amy Ming Fang Yen
, Sam Li Sheng Chen
, Chen Yang Hsu
, Sherry Yueh Hsia Chiu
, Jean Ching Yuan Fann
, Yi Chia Lee
, Han Mo Chiu
, Shu Chun Hsiao
, Tsui Hsia Hsu
, Hsiu Hsi Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

16 Scopus citations

Abstract

Background: To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods: We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012. Results: The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01-1.24) and 1.00 (0.91-1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P <.05). However, treatment at medical center had a lower mortality (0.83, 0.75-0.91) than local/regional hospital. Conclusions: Treatment delay longer than 6 weeks for OSCCs detected via a population-based screening program had unfavorable survival.

Original language	English
Pages (from-to)	473-484
Number of pages	12
Journal	Head and Neck
Volume	43
Issue number	2
DOIs	https://doi.org/10.1002/hed.26504
State	Published - 02 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.

Keywords

betel quid chewing
cigarette smoking
oral/oropharyngeal cancer
survival
treatment delay

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.26504

Cite this

@article{0993e179e4eb40d5a78affe9b83801f8,

title = "Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program",

abstract = "Background: To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods: We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012. Results: The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01-1.24) and 1.00 (0.91-1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P <.05). However, treatment at medical center had a lower mortality (0.83, 0.75-0.91) than local/regional hospital. Conclusions: Treatment delay longer than 6 weeks for OSCCs detected via a population-based screening program had unfavorable survival.",

keywords = "betel quid chewing, cigarette smoking, oral/oropharyngeal cancer, survival, treatment delay",

author = "Su, \{William Wang Yu\} and Lee, \{Yi Huah\} and Yen, \{Amy Ming Fang\} and Chen, \{Sam Li Sheng\} and Hsu, \{Chen Yang\} and Chiu, \{Sherry Yueh Hsia\} and Fann, \{Jean Ching Yuan\} and Lee, \{Yi Chia\} and Chiu, \{Han Mo\} and Hsiao, \{Shu Chun\} and Hsu, \{Tsui Hsia\} and Chen, \{Hsiu Hsi\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Head \& Neck published by Wiley Periodicals LLC.",

year = "2021",

month = feb,

doi = "10.1002/hed.26504",

language = "英语",

volume = "43",

pages = "473--484",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley \& Sons Inc.",

number = "2",

}

TY - JOUR

T1 - Impact of treatment delay on survival of oral/oropharyngeal cancers

T2 - Results of a nationwide screening program

AU - Su, William Wang Yu

AU - Lee, Yi Huah

AU - Yen, Amy Ming Fang

AU - Chen, Sam Li Sheng

AU - Hsu, Chen Yang

AU - Chiu, Sherry Yueh Hsia

AU - Fann, Jean Ching Yuan

AU - Lee, Yi Chia

AU - Chiu, Han Mo

AU - Hsiao, Shu Chun

AU - Hsu, Tsui Hsia

AU - Chen, Hsiu Hsi

PY - 2021/2

Y1 - 2021/2

N2 - Background: To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods: We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012. Results: The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01-1.24) and 1.00 (0.91-1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P <.05). However, treatment at medical center had a lower mortality (0.83, 0.75-0.91) than local/regional hospital. Conclusions: Treatment delay longer than 6 weeks for OSCCs detected via a population-based screening program had unfavorable survival.

AB - Background: To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods: We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012. Results: The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01-1.24) and 1.00 (0.91-1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P <.05). However, treatment at medical center had a lower mortality (0.83, 0.75-0.91) than local/regional hospital. Conclusions: Treatment delay longer than 6 weeks for OSCCs detected via a population-based screening program had unfavorable survival.

KW - betel quid chewing

KW - cigarette smoking

KW - oral/oropharyngeal cancer

KW - survival

KW - treatment delay

UR - https://www.scopus.com/pages/publications/85092360644

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M3 - 文章

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SN - 1043-3074

VL - 43

SP - 473

EP - 484

JO - Head and Neck

JF - Head and Neck

IS - 2

ER -

Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program

Abstract

Bibliographical note

Keywords

UN SDGs

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