IMPEDIMETRIC MEASUREMENT OF 3D ANGIOGENIC PROCESS

Chun Hao Huang; Kin Fong Lei

IMPEDIMETRIC MEASUREMENT OF 3D ANGIOGENIC PROCESS

Chun Hao Huang
, Kin Fong Lei^*

^*Corresponding author for this work

Master Program in Nano-Electronic Engineering and Design

Chang Gung University
Chang Gung Memorial Hospital

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this research, a microfluidic biochip for impedance measurement was developed to explore the angiogenesis ability affected by VEGF in a 3D microenvironment. The process of angiogenesis and invasion of human umbilical vein endothelial cells (HUVEC) is studied by using microfluidic technology and bio colloids (Matrigel) to construct a 3D biological barrier. During angiogenesis affected by different concentrations of vascular endothelial growth factor (VEGF), the impedance changes and time points were recorded to analyze the angiogenesis ability. The results showed that the impedance measurement can quantify the angiogenesis ability in the microfluidic biochip in real-time.

Original language	English
Title of host publication	MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	345-346
Number of pages	2
ISBN (Electronic)	9781733419031
State	Published - 2021
Event	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Palm Springs, Virtual, United States Duration: 10 10 2021 → 14 10 2021

Publication series

Name	MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Country/Territory	United States
City	Palm Springs, Virtual
Period	10/10/21 → 14/10/21

Bibliographical note

Publisher Copyright:
© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

Keywords

3D culture
Angiogenesis
Impedance measurement
Microfluidic biochip

Cite this

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title = "IMPEDIMETRIC MEASUREMENT OF 3D ANGIOGENIC PROCESS",

abstract = "In this research, a microfluidic biochip for impedance measurement was developed to explore the angiogenesis ability affected by VEGF in a 3D microenvironment. The process of angiogenesis and invasion of human umbilical vein endothelial cells (HUVEC) is studied by using microfluidic technology and bio colloids (Matrigel) to construct a 3D biological barrier. During angiogenesis affected by different concentrations of vascular endothelial growth factor (VEGF), the impedance changes and time points were recorded to analyze the angiogenesis ability. The results showed that the impedance measurement can quantify the angiogenesis ability in the microfluidic biochip in real-time.",

keywords = "3D culture, Angiogenesis, Impedance measurement, Microfluidic biochip",

author = "Huang, \{Chun Hao\} and Lei, \{Kin Fong\}",

note = "Publisher Copyright: {\textcopyright} 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.; 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 ; Conference date: 10-10-2021 Through 14-10-2021",

year = "2021",

language = "英语",

series = "MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "Chemical and Biological Microsystems Society",

pages = "345--346",

booktitle = "MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

}

Huang, CH & Lei, KF 2021, IMPEDIMETRIC MEASUREMENT OF 3D ANGIOGENIC PROCESS. in MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 345-346, 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021, Palm Springs, Virtual, United States, 10/10/21.

IMPEDIMETRIC MEASUREMENT OF 3D ANGIOGENIC PROCESS. / Huang, Chun Hao; Lei, Kin Fong.
MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2021. p. 345-346 (MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - IMPEDIMETRIC MEASUREMENT OF 3D ANGIOGENIC PROCESS

AU - Huang, Chun Hao

AU - Lei, Kin Fong

PY - 2021

Y1 - 2021

N2 - In this research, a microfluidic biochip for impedance measurement was developed to explore the angiogenesis ability affected by VEGF in a 3D microenvironment. The process of angiogenesis and invasion of human umbilical vein endothelial cells (HUVEC) is studied by using microfluidic technology and bio colloids (Matrigel) to construct a 3D biological barrier. During angiogenesis affected by different concentrations of vascular endothelial growth factor (VEGF), the impedance changes and time points were recorded to analyze the angiogenesis ability. The results showed that the impedance measurement can quantify the angiogenesis ability in the microfluidic biochip in real-time.

AB - In this research, a microfluidic biochip for impedance measurement was developed to explore the angiogenesis ability affected by VEGF in a 3D microenvironment. The process of angiogenesis and invasion of human umbilical vein endothelial cells (HUVEC) is studied by using microfluidic technology and bio colloids (Matrigel) to construct a 3D biological barrier. During angiogenesis affected by different concentrations of vascular endothelial growth factor (VEGF), the impedance changes and time points were recorded to analyze the angiogenesis ability. The results showed that the impedance measurement can quantify the angiogenesis ability in the microfluidic biochip in real-time.

KW - 3D culture

KW - Angiogenesis

KW - Impedance measurement

KW - Microfluidic biochip

UR - https://www.scopus.com/pages/publications/85136970417

M3 - 会议稿件

AN - SCOPUS:85136970417

T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

SP - 345

EP - 346

BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021

Y2 - 10 October 2021 through 14 October 2021

ER -

IMPEDIMETRIC MEASUREMENT OF 3D ANGIOGENIC PROCESS

Abstract

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Bibliographical note

Keywords

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Cite this