Implementations of clinical functional magnetic resonance imaging using character-based paradigms for the prediction of Chinese language dominance

Ho-Ling Liu*, Chien Te Wu, Jian Chuan Chen, Yuan Yu Hsu, Yau-Yau Wai, Yung Liang Wan

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations

Abstract

Purpose: Recently, functional MRI (fMRI) using word generation (WG) tasks has been shown to be effective for mapping the Chinese language-related brain areas. In clinical applications, however, patients' performance cannot be easily monitored during WG tasks. In this study, we evaluated the feasibility of a word choice (WC) paradigm in the clinical setting and compared the results with those from WG tasks. Method: Intrasubject comparisons of fMRI with both WG and WC paradigms were performed on six normal human subjects and two tumor patients. Subject responses in the WC paradigm, based on semantic judgments, were recorded. Activation strength, extent, and laterality were evaluated and compared. Results: Our results showed that fMRI with the WC paradigm evoked weaker neuronal activation than that with the WG paradigm in Chinese language-related brain areas. It was sufficient to reveal language laterality for clinical use, however. In addition, it resulted in less nonlanguage-specific brain activation. Conclusion: Results from the patient data demonstrated strong evidence for the necessity of incorporating response monitoring during fMRI studies, which suggested that fMRI with the WC paradigm is more appropriate to be implemented for the prediction of Chinese language dominance in clinical environments.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalJournal of Computer Assisted Tomography
Volume27
Issue number2
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Chinese language
  • Functional magnetic resonance imaging
  • Language dominance
  • Magnetic resonance imaging
  • Word generation

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