TY - JOUR
T1 - Implementations of clinical functional magnetic resonance imaging using character-based paradigms for the prediction of Chinese language dominance
AU - Liu, Ho-Ling
AU - Wu, Chien Te
AU - Chen, Jian Chuan
AU - Hsu, Yuan Yu
AU - Wai, Yau-Yau
AU - Wan, Yung Liang
PY - 2003
Y1 - 2003
N2 - Purpose: Recently, functional MRI (fMRI) using word generation (WG) tasks has been shown to be effective for mapping the Chinese language-related brain areas. In clinical applications, however, patients' performance cannot be easily monitored during WG tasks. In this study, we evaluated the feasibility of a word choice (WC) paradigm in the clinical setting and compared the results with those from WG tasks. Method: Intrasubject comparisons of fMRI with both WG and WC paradigms were performed on six normal human subjects and two tumor patients. Subject responses in the WC paradigm, based on semantic judgments, were recorded. Activation strength, extent, and laterality were evaluated and compared. Results: Our results showed that fMRI with the WC paradigm evoked weaker neuronal activation than that with the WG paradigm in Chinese language-related brain areas. It was sufficient to reveal language laterality for clinical use, however. In addition, it resulted in less nonlanguage-specific brain activation. Conclusion: Results from the patient data demonstrated strong evidence for the necessity of incorporating response monitoring during fMRI studies, which suggested that fMRI with the WC paradigm is more appropriate to be implemented for the prediction of Chinese language dominance in clinical environments.
AB - Purpose: Recently, functional MRI (fMRI) using word generation (WG) tasks has been shown to be effective for mapping the Chinese language-related brain areas. In clinical applications, however, patients' performance cannot be easily monitored during WG tasks. In this study, we evaluated the feasibility of a word choice (WC) paradigm in the clinical setting and compared the results with those from WG tasks. Method: Intrasubject comparisons of fMRI with both WG and WC paradigms were performed on six normal human subjects and two tumor patients. Subject responses in the WC paradigm, based on semantic judgments, were recorded. Activation strength, extent, and laterality were evaluated and compared. Results: Our results showed that fMRI with the WC paradigm evoked weaker neuronal activation than that with the WG paradigm in Chinese language-related brain areas. It was sufficient to reveal language laterality for clinical use, however. In addition, it resulted in less nonlanguage-specific brain activation. Conclusion: Results from the patient data demonstrated strong evidence for the necessity of incorporating response monitoring during fMRI studies, which suggested that fMRI with the WC paradigm is more appropriate to be implemented for the prediction of Chinese language dominance in clinical environments.
KW - Chinese language
KW - Functional magnetic resonance imaging
KW - Language dominance
KW - Magnetic resonance imaging
KW - Word generation
UR - http://www.scopus.com/inward/record.url?scp=0038390150&partnerID=8YFLogxK
U2 - 10.1097/00004728-200303000-00017
DO - 10.1097/00004728-200303000-00017
M3 - 文章
C2 - 12703013
AN - SCOPUS:0038390150
SN - 0363-8715
VL - 27
SP - 207
EP - 212
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
IS - 2
ER -