Importance of FSH-releasing protein and inhibin in erythrodifferentiation

John Yu*, Li En Shao, Victor Lemas, Alice L. Yu, Joan Vaughan, Jean Rivier, Wylie Vale

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

276 Scopus citations

Abstract

Inhibin is a hypophysiotropic hormone which selectively suppresses the secretion of pituitary follicle-stimulating hormone. It has been isolated from gonadal fluids and characterized as a protein heterodimer consisting of an α subunit and one of two β subunits (βA or βB)1-4. FSH-releasing protein (FRP), also named activin, is a dimer consisting of two inhibin β-chains5-6. A factor from conditioned medium of a leukaemia cell line has been isolated which can induce mouse Friend cells to become benzidine-positive, and which shares a similar N-terminal sequence with porcine FRP7. In this report, we find that FRP and inhibin modulate both the induction of haemoglobin accumulation in a human erythroleukaemic cell line, K562, and the proliferation of erythroid progenitor cells in human bone marrow culture. These two proteins could constitute a novel humoral regulatory control of erythropoiesis which would involve two types of related protein dimers with functionally opposite effects.

Original languageEnglish
Pages (from-to)765-767
Number of pages3
JournalNature
Volume330
Issue number6150
DOIs
StatePublished - 1987
Externally publishedYes

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