TY - JOUR
T1 - Importance of hyperhomocysteinemia as a risk factor for venous thromboembolism in a Taiwanese population. A case-control study
AU - Hsu, Tsu Shiu
AU - Hsu, Lung An
AU - Chang, Chi Jen
AU - Sun, Chien Feng
AU - Ko, Yu Lin
AU - Kuo, Chi Tai
AU - Chiang, Cheng Wen
AU - Lee, Ying Shiung
PY - 2001/6/1
Y1 - 2001/6/1
N2 - Objective: To determine the current status of hyperhomocysteinemia, which is a known risk for venous thrombosis (DVT), in Taiwan. Subjects: 101 unselected patients with a minimum of one episode of deep leg DVT, either initial inpatients or current compliant outpatients in a teaching hospital. Methods: Various thrombophilic risks, gene polymorphism and clinical predisposition were evaluated. Results and conclusions: Patients presented higher fast total plasma homocysteine (hcy) levels than age- and sex-matched controls did (14.1 vs. 9.94 μM). Based on the 95th percentile of control values, hyperhomocysteinemia had a four- to nine-fold risk for DVT, irrespective of clinical predisposition, as well as other thrombophilic risks surveyed. Polymorphism of a metabolizing enzyme, methylenetetrahydrofolate reductase (MTHFR), was not associated with DVT, although homozygous thermolabile mutation tended to have higher plasma hcy levels. Factor V Leiden was absent in analysis of 80 patients. In complete evaluation (hcy, antithrombin (AT), protein S (PS), protein C (PC), lupus anticoagulant (LA), anticardiolipin antibody) of a subset of 83 patients hyperhomocysteinemia was the most prevalent risk (33.7%), with PC or PS deficiencies following (22.9%). Thus, hyperhomocysteinemia is a prominent risk for DVT in Taiwan.
AB - Objective: To determine the current status of hyperhomocysteinemia, which is a known risk for venous thrombosis (DVT), in Taiwan. Subjects: 101 unselected patients with a minimum of one episode of deep leg DVT, either initial inpatients or current compliant outpatients in a teaching hospital. Methods: Various thrombophilic risks, gene polymorphism and clinical predisposition were evaluated. Results and conclusions: Patients presented higher fast total plasma homocysteine (hcy) levels than age- and sex-matched controls did (14.1 vs. 9.94 μM). Based on the 95th percentile of control values, hyperhomocysteinemia had a four- to nine-fold risk for DVT, irrespective of clinical predisposition, as well as other thrombophilic risks surveyed. Polymorphism of a metabolizing enzyme, methylenetetrahydrofolate reductase (MTHFR), was not associated with DVT, although homozygous thermolabile mutation tended to have higher plasma hcy levels. Factor V Leiden was absent in analysis of 80 patients. In complete evaluation (hcy, antithrombin (AT), protein S (PS), protein C (PC), lupus anticoagulant (LA), anticardiolipin antibody) of a subset of 83 patients hyperhomocysteinemia was the most prevalent risk (33.7%), with PC or PS deficiencies following (22.9%). Thus, hyperhomocysteinemia is a prominent risk for DVT in Taiwan.
KW - Hyperhomocysteinemia
KW - Venous thromboembolism
UR - http://www.scopus.com/inward/record.url?scp=0035370630&partnerID=8YFLogxK
U2 - 10.1016/S0049-3848(01)00262-6
DO - 10.1016/S0049-3848(01)00262-6
M3 - 文章
C2 - 11395124
AN - SCOPUS:0035370630
SN - 0049-3848
VL - 102
SP - 387
EP - 395
JO - Thrombosis Research
JF - Thrombosis Research
IS - 5
ER -