Improving bioactivity in 3D-printed Ti-6Al-4V alloy scaffold via CaO-MgO-SiO2 glass-ceramic coating

Yan Ting Chen; Hui Yi Hsiao; Chi Yun Wang; Chi Shun Tu; Kuei Chih Feng; Haidee Mana-ay; Shyang Yih Kung; Pin Yi Chen; Po Liang Lai

doi:10.1016/j.jallcom.2023.173387

Improving bioactivity in 3D-printed Ti-6Al-4V alloy scaffold via CaO-MgO-SiO₂ glass-ceramic coating

Yan Ting Chen, Hui Yi Hsiao, Chi Yun Wang, Chi Shun Tu, Kuei Chih Feng, Haidee Mana-ay, Shyang Yih Kung, Pin Yi Chen^*, Po Liang Lai^*

^*Corresponding author for this work

Department of Biomedical Sciences (Master's Program in Clinical Trials Assessment)

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

Abstract

This work proposes an effective design of bioactive 3D-printed Ti-6Al-4V scaffold with the CaO-MgO-SiO₂ glass-ceramic coating to realize a comparable elastic modulus of bone tissue and boost osteogenic differentiation. The improved elastic modulus and stiffness of Ti alloy were achieved via effectively increasing surface area of Ti alloy to reduce stress shielding effect. A hydrophilic surface and bioactive glass-ceramic coating were conducted via chemical etching and heat-treatment under argon atmosphere to enhance cells attachment and boost cell proliferation and osteogenic differentiation. The expression of osteogenic genes in bioactive CaO-MgO-SiO₂ glass-ceramic was evaluated through ALP, OPN, Runx2, and Col1A1 gene markers to explore the mechanism of superior osteogenic differentiation. Significant increase in OPN expression level confirmed the effect of CaO-MgO-SiO₂ coating for the enhancement of osteogenic bioactivity. This work provides a feasible approach through surface etching and bioactive CaO-MgO-SiO₂ glass-ceramic coating on the Ti alloy surface to enhance bioactivity and osteogenesis.

Original language	English
Article number	173387
Journal	Journal of Alloys and Compounds
Volume	976
DOIs	https://doi.org/10.1016/j.jallcom.2023.173387
State	Published - 05 03 2024

Bibliographical note

Publisher Copyright:
© 2024 Elsevier B.V.

Keywords

3D printing
Bioactive coating
CaO-MgO-SiO bioglass-ceramics
Implants
Ti-6Al-4V

Access to Document

10.1016/j.jallcom.2023.173387

Cite this

@article{8ac4c181aa184306ac49159b4b3aa520,

title = "Improving bioactivity in 3D-printed Ti-6Al-4V alloy scaffold via CaO-MgO-SiO2 glass-ceramic coating",

abstract = "This work proposes an effective design of bioactive 3D-printed Ti-6Al-4V scaffold with the CaO-MgO-SiO2 glass-ceramic coating to realize a comparable elastic modulus of bone tissue and boost osteogenic differentiation. The improved elastic modulus and stiffness of Ti alloy were achieved via effectively increasing surface area of Ti alloy to reduce stress shielding effect. A hydrophilic surface and bioactive glass-ceramic coating were conducted via chemical etching and heat-treatment under argon atmosphere to enhance cells attachment and boost cell proliferation and osteogenic differentiation. The expression of osteogenic genes in bioactive CaO-MgO-SiO2 glass-ceramic was evaluated through ALP, OPN, Runx2, and Col1A1 gene markers to explore the mechanism of superior osteogenic differentiation. Significant increase in OPN expression level confirmed the effect of CaO-MgO-SiO2 coating for the enhancement of osteogenic bioactivity. This work provides a feasible approach through surface etching and bioactive CaO-MgO-SiO2 glass-ceramic coating on the Ti alloy surface to enhance bioactivity and osteogenesis.",

keywords = "3D printing, Bioactive coating, CaO-MgO-SiO bioglass-ceramics, Implants, Ti-6Al-4V",

author = "Chen, \{Yan Ting\} and Hsiao, \{Hui Yi\} and Wang, \{Chi Yun\} and Tu, \{Chi Shun\} and Feng, \{Kuei Chih\} and Haidee Mana-ay and Kung, \{Shyang Yih\} and Chen, \{Pin Yi\} and Lai, \{Po Liang\}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier B.V.",

year = "2024",

month = mar,

day = "5",

doi = "10.1016/j.jallcom.2023.173387",

language = "英语",

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AU - Chen, Yan Ting

AU - Hsiao, Hui Yi

AU - Wang, Chi Yun

AU - Tu, Chi Shun

AU - Feng, Kuei Chih

AU - Mana-ay, Haidee

AU - Kung, Shyang Yih

AU - Chen, Pin Yi

AU - Lai, Po Liang

PY - 2024/3/5

Y1 - 2024/3/5

N2 - This work proposes an effective design of bioactive 3D-printed Ti-6Al-4V scaffold with the CaO-MgO-SiO2 glass-ceramic coating to realize a comparable elastic modulus of bone tissue and boost osteogenic differentiation. The improved elastic modulus and stiffness of Ti alloy were achieved via effectively increasing surface area of Ti alloy to reduce stress shielding effect. A hydrophilic surface and bioactive glass-ceramic coating were conducted via chemical etching and heat-treatment under argon atmosphere to enhance cells attachment and boost cell proliferation and osteogenic differentiation. The expression of osteogenic genes in bioactive CaO-MgO-SiO2 glass-ceramic was evaluated through ALP, OPN, Runx2, and Col1A1 gene markers to explore the mechanism of superior osteogenic differentiation. Significant increase in OPN expression level confirmed the effect of CaO-MgO-SiO2 coating for the enhancement of osteogenic bioactivity. This work provides a feasible approach through surface etching and bioactive CaO-MgO-SiO2 glass-ceramic coating on the Ti alloy surface to enhance bioactivity and osteogenesis.

AB - This work proposes an effective design of bioactive 3D-printed Ti-6Al-4V scaffold with the CaO-MgO-SiO2 glass-ceramic coating to realize a comparable elastic modulus of bone tissue and boost osteogenic differentiation. The improved elastic modulus and stiffness of Ti alloy were achieved via effectively increasing surface area of Ti alloy to reduce stress shielding effect. A hydrophilic surface and bioactive glass-ceramic coating were conducted via chemical etching and heat-treatment under argon atmosphere to enhance cells attachment and boost cell proliferation and osteogenic differentiation. The expression of osteogenic genes in bioactive CaO-MgO-SiO2 glass-ceramic was evaluated through ALP, OPN, Runx2, and Col1A1 gene markers to explore the mechanism of superior osteogenic differentiation. Significant increase in OPN expression level confirmed the effect of CaO-MgO-SiO2 coating for the enhancement of osteogenic bioactivity. This work provides a feasible approach through surface etching and bioactive CaO-MgO-SiO2 glass-ceramic coating on the Ti alloy surface to enhance bioactivity and osteogenesis.

KW - 3D printing

KW - Bioactive coating

KW - CaO-MgO-SiO bioglass-ceramics

KW - Implants

KW - Ti-6Al-4V

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