TY - JOUR
T1 - Improving bone microarchitecture in aging with diosgenin treatment
T2 - A study in senescence-accelerated OXYS rats
AU - Tikhonova, Maria A.
AU - Ting, Che Hao
AU - Kolosova, Nataliya G.
AU - Hsu, Chao Yu
AU - Chen, Jian Horng
AU - Huang, Chi Wen
AU - Tseng, Ging Ting
AU - Hung, Ching Sui
AU - Kao, Pan Fu
AU - Amstislavskaya, Tamara G.
AU - Ho, Ying Jui
N1 - Publisher Copyright:
© 2015 by The Chinese Physiological Society and Airiti Press Inc.
PY - 2015
Y1 - 2015
N2 - Osteoporosis is a major disease associated with aging. We have previously demonstrated that diosgenin prevents osteoporosis in both menopause and D-galactose-induced aging rats. OXYS rats reveal an accelerated senescence and are used as a suitable model of osteoporosis. The aim of the present study was to analyze microarchitecture and morphological changes in femur of OXYS rats using morphological tests and microcomputed tomography scanning, and to evaluate the effects of oral administration of diosgenin at 10 and 50 mg/kg/day on femur in OXYS rats. The result showed that, compared with age-matched Wistar rats, the femur of OXYS rats revealed lower bone length, bone weight, bone volume, frame volume, frame density, void volume, porosity, external and internal diameters, cortical bone area, BV/TV, Tb.N, and Tb.Th, but higher Tb.Sp. Eight weeks of diosgenin treatment decreased porosity and Tb.Sp, but increased BV/TV, cortical bone area, Tb.N and bone mineral density, compared with OXYS rats treated with vehicle. These data reveal that microarchitecture and morphological changes in femur of OXYS rats showed osteoporotic aging features and suggest that diosgenin may have beneficial effects on aging-induced osteoporosis.
AB - Osteoporosis is a major disease associated with aging. We have previously demonstrated that diosgenin prevents osteoporosis in both menopause and D-galactose-induced aging rats. OXYS rats reveal an accelerated senescence and are used as a suitable model of osteoporosis. The aim of the present study was to analyze microarchitecture and morphological changes in femur of OXYS rats using morphological tests and microcomputed tomography scanning, and to evaluate the effects of oral administration of diosgenin at 10 and 50 mg/kg/day on femur in OXYS rats. The result showed that, compared with age-matched Wistar rats, the femur of OXYS rats revealed lower bone length, bone weight, bone volume, frame volume, frame density, void volume, porosity, external and internal diameters, cortical bone area, BV/TV, Tb.N, and Tb.Th, but higher Tb.Sp. Eight weeks of diosgenin treatment decreased porosity and Tb.Sp, but increased BV/TV, cortical bone area, Tb.N and bone mineral density, compared with OXYS rats treated with vehicle. These data reveal that microarchitecture and morphological changes in femur of OXYS rats showed osteoporotic aging features and suggest that diosgenin may have beneficial effects on aging-induced osteoporosis.
KW - Aging
KW - Bone loss
KW - Diosgenin
KW - Microcomputed tomography
KW - OXYS rats
KW - Osteoporosis
UR - http://www.scopus.com/inward/record.url?scp=84946923211&partnerID=8YFLogxK
U2 - 10.4077/CJP.2015.BAD325
DO - 10.4077/CJP.2015.BAD325
M3 - 文章
C2 - 26387656
AN - SCOPUS:84946923211
SN - 0304-4920
VL - 58
SP - 322
EP - 331
JO - Chinese Journal of Physiology
JF - Chinese Journal of Physiology
IS - 5
ER -