TY - JOUR
T1 - In vitro antileishmanial activity of Aloe vera leaf exudate
T2 - A potential herbal therapy in leishmaniasis
AU - Dutta, Avijit
AU - Mandal, Goutam
AU - Mandal, Chitra
AU - Chatterjee, Mitali
PY - 2007/1
Y1 - 2007/1
N2 - Aloe vera has wide spread use in health products, and despite several reports on the whole plant and inner gel, little work has been performed on the leaf exudate. Our aim was to evaluate the in vitro efficacy of Aloe vera leaf exudate (AVL) in leishmaniasis. Irrespective of the disease manifestation, promastigotes from strains responsible for cutaneous, mucocutaneous, and visceral leishmaniasis were susceptible to AVL and their IC50 ranged from 100 to 180 μg/ml. In axenic amastigotes cultured from a L. donovani strain 2001 responsible for visceral leishmaniasis, the IC50 was 6.0 μg/ml. AVL caused activation of host macrophages evident by an increased release of members of reactive oxygen species that was attenuated by preincubation with free radical scavengers. Collectively, our data indicates that AVL, via its direct leishmanicidal activity which can be further enhanced by activation of host macrophages, is an effective antileishmanial agent meriting further pharmacological investigations.
AB - Aloe vera has wide spread use in health products, and despite several reports on the whole plant and inner gel, little work has been performed on the leaf exudate. Our aim was to evaluate the in vitro efficacy of Aloe vera leaf exudate (AVL) in leishmaniasis. Irrespective of the disease manifestation, promastigotes from strains responsible for cutaneous, mucocutaneous, and visceral leishmaniasis were susceptible to AVL and their IC50 ranged from 100 to 180 μg/ml. In axenic amastigotes cultured from a L. donovani strain 2001 responsible for visceral leishmaniasis, the IC50 was 6.0 μg/ml. AVL caused activation of host macrophages evident by an increased release of members of reactive oxygen species that was attenuated by preincubation with free radical scavengers. Collectively, our data indicates that AVL, via its direct leishmanicidal activity which can be further enhanced by activation of host macrophages, is an effective antileishmanial agent meriting further pharmacological investigations.
KW - Aloe vera
KW - Antileishmanial
KW - Leishmaniasis
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=33845568277&partnerID=8YFLogxK
U2 - 10.1007/s10719-006-9014-z
DO - 10.1007/s10719-006-9014-z
M3 - 文章
C2 - 17146713
AN - SCOPUS:33845568277
SN - 0282-0080
VL - 24
SP - 81
EP - 86
JO - Glycoconjugate Journal
JF - Glycoconjugate Journal
IS - 1
ER -