In vitro biocompatibility, radiopacity, and physical property tests of nano-Fe3O4 incorporated poly-L-lactide bone screws

Hsin Ta Wang, Pao Chang Chiang, Jy Jiunn Tzeng, Ting Lin Wu, Yu Hwa Pan, Wei Jen Chang*, Haw Ming Huang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

17 Scopus citations

Abstract

The aim of this study was to fabricate biodegradable poly-L-lactic acid (PLLA) bone screws containing iron oxide (Fe3O4) nanoparticles, which are radiopaque and 3D-printable. The PLLA composites were fabricated by loading 20%, 30%, and 40% Fe3O4 nanoparticles into the PLLA. The physical properties, including elastic modulus, thermal properties, and biocompatibility of the composites were tested. The 20% nano-Fe3O4/PLLA composite was used as the material for fabricating the 3D-printed bone screws. The mechanical performance of the nano-Fe3O4/PLLA bone screws was evaluated by anti-bending and anti-torque strength tests. The tissue response and radiopacity of the nano-Fe3O4/PLLA bone screws were assessed by histologic and CT imaging studies using an animal model. The addition of nano-Fe3O4 increased the crystallization of the PLLA composites. Furthermore, the 20% nano-Fe3O4/PLLA composite exhibited the highest thermal stability compared to the other Fe3O4 proportions. The 3D-printed bone screws using the 20% nano-Fe3O4/PLLA composite provided excellent local tissue response. In addition, the radiopacity of the 20% nano-Fe3O4/PLLA screw was significantly better compared with the neat PLLA screw.

Original languageEnglish
Article number191
JournalPolymers
Volume9
Issue number6
DOIs
StatePublished - 01 06 2017

Bibliographical note

Publisher Copyright:
© 2017 by the authors.

Keywords

  • 3D printed bone screw
  • Iron oxide nanoparticles
  • Poly-L-lactic acid
  • Radiopaque polymer

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