In vitro dynamic fertilization by using EWOD device

Lung Yuan Chung, Hsien Hua Shen, Yu Hsiang Chung, Chih Chen Chen, Chia Hsien Hsu, Hong Yuan Huang, Da Jeng Yao

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This research demonstrates the in vitro fertilization (IVF) technique by using the digital microfluidic (DMF) system. The DMF device has been proved with biocompatibility and used in this research for mouse gametes in vitro fertilization and embryos culture based on the dispersed droplet form. Dynamically moving, cell culture and observation can be achieved by the time-lapse microscopy in an incubator. The fertilization rate of IVF on DMF is 34.8%, and about 25% inseminated embryos dynamically cultured on DMF chip could develop into 8-cell stage. The result indicated that the DMF system has the potential used for assisted reproductive technology.

Original languageEnglish
Title of host publication2015 28th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages519-522
Number of pages4
EditionFebruary
ISBN (Electronic)9781479979554
DOIs
StatePublished - 26 02 2015
Externally publishedYes
Event2015 28th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2015 - Estoril, Portugal
Duration: 18 01 201522 01 2015

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
NumberFebruary
Volume2015-February
ISSN (Print)1084-6999

Conference

Conference2015 28th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2015
Country/TerritoryPortugal
CityEstoril
Period18/01/1522/01/15

Bibliographical note

Publisher Copyright:
© 2015 IEEE.

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