In vivo assessment of macrophage CNS infiltration during disruption of the blood-brain barrier with focused ultrasound: A magnetic resonance imaging study

Hao Li Liu; Yau Yau Wai; Po Hong Hsu; Lee Ang Lyu; Jia Shin Wu; Chia Rui Shen; Jin Chung Chen; Tzu Chen Yen; Jiun Jie Wang

doi:10.1038/jcbfm.2009.179

In vivo assessment of macrophage CNS infiltration during disruption of the blood-brain barrier with focused ultrasound: A magnetic resonance imaging study

Hao Li Liu, Yau Yau Wai, Po Hong Hsu, Lee Ang Lyu, Jia Shin Wu, Chia Rui Shen, Jin Chung Chen, Tzu Chen Yen, Jiun Jie Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

30 Scopus citations

Abstract

Focused ultrasound has been discovered to locally and reversibly increase permeability of the blood-brain barrier (BBB). However, inappropriate sonication of the BBB may cause complications, such as hemorrhage and brain tissue damage. Tissue damage may be controlled by selecting optimal sonication parameters. In this study, we sought to investigate the feasibility of labeling cells with superparamagnetic iron oxide particles to assess the inflammatory response during focused-ultrasound-induced BBB opening. We show that infiltration of phagocytes does not occur using optimal parameters of sonication. Taken together, the results of our study support the usefulness and safety of focused-ultrasound-induced BBB opening for enhancing drug delivery to the brain. These findings may have implications for the optimization of sonication parameters.

Original language	English
Pages (from-to)	177-186
Number of pages	10
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	30
Issue number	1
DOIs	https://doi.org/10.1038/jcbfm.2009.179
State	Published - 01 2010

Keywords

Blood-brain barrier disruption
Focused ultrasound
Inflammation
SPIO-labeled cellular imaging

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10.1038/jcbfm.2009.179

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Liu, H. L., Wai, Y. Y., Hsu, P. H., Lyu, L. A., Wu, J. S., Shen, C. R., Chen, J. C., Yen, T. C., & Wang, J. J. (2010). In vivo assessment of macrophage CNS infiltration during disruption of the blood-brain barrier with focused ultrasound: A magnetic resonance imaging study. Journal of Cerebral Blood Flow and Metabolism, 30(1), 177-186. https://doi.org/10.1038/jcbfm.2009.179

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abstract = "Focused ultrasound has been discovered to locally and reversibly increase permeability of the blood-brain barrier (BBB). However, inappropriate sonication of the BBB may cause complications, such as hemorrhage and brain tissue damage. Tissue damage may be controlled by selecting optimal sonication parameters. In this study, we sought to investigate the feasibility of labeling cells with superparamagnetic iron oxide particles to assess the inflammatory response during focused-ultrasound-induced BBB opening. We show that infiltration of phagocytes does not occur using optimal parameters of sonication. Taken together, the results of our study support the usefulness and safety of focused-ultrasound-induced BBB opening for enhancing drug delivery to the brain. These findings may have implications for the optimization of sonication parameters.",

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AU - Lyu, Lee Ang

AU - Wu, Jia Shin

AU - Shen, Chia Rui

AU - Chen, Jin Chung

AU - Yen, Tzu Chen

AU - Wang, Jiun Jie

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AB - Focused ultrasound has been discovered to locally and reversibly increase permeability of the blood-brain barrier (BBB). However, inappropriate sonication of the BBB may cause complications, such as hemorrhage and brain tissue damage. Tissue damage may be controlled by selecting optimal sonication parameters. In this study, we sought to investigate the feasibility of labeling cells with superparamagnetic iron oxide particles to assess the inflammatory response during focused-ultrasound-induced BBB opening. We show that infiltration of phagocytes does not occur using optimal parameters of sonication. Taken together, the results of our study support the usefulness and safety of focused-ultrasound-induced BBB opening for enhancing drug delivery to the brain. These findings may have implications for the optimization of sonication parameters.

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In vivo assessment of macrophage CNS infiltration during disruption of the blood-brain barrier with focused ultrasound: A magnetic resonance imaging study

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Keywords

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