In vivo correlation between semi-quantitative hemodynamic parameters and K trans derived from DCE-MRI of brain tumors

Chih Feng Chen; Ling Wei Hsu; Chun Chung Lui; Chen Chang Lee; Hsu Huei Weng; Yuan Hsiung Tsai; Ho Ling Liu

doi:10.1002/ima.22013

In vivo correlation between semi-quantitative hemodynamic parameters and K ^trans derived from DCE-MRI of brain tumors

Chih Feng Chen
, Ling Wei Hsu
, Chun Chung Lui
, Chen Chang Lee
, Hsu Huei Weng
, Yuan Hsiung Tsai
, Ho Ling Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

7 Scopus citations

Abstract

Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) has become more and more widely applied in cancer diagnosis and treatment follow-up. Without complicated calculation, a semiquantitative parameter - modified initial area under the curve (mIAUC _c) - was proposed for better correlation with volume transfer constant (K ^trans) by computer simulation. In this study, we aim to further investigate the correlation between mIAUC _c and K ^trans in clinical. A total of 10 patients with brain tumors participated in this study and images were acquired by using a 3-Tesla clinical MR scanner. The results showed that mIAUC _c was highly correlated with K ^trans with the correlation coefficient of 0.913. Although the ideals of K ^trans and mIAUC _c are different, mIAUC _c does the trick for brain tumors evaluations in DCE-MRI. It reveals that mIAUC _c could be an alternative for physiological condition evaluation in DCE-MRI.

Original language	English
Pages (from-to)	132-136
Number of pages	5
Journal	International Journal of Imaging Systems and Technology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1002/ima.22013
State	Published - 06 2012
Externally published	Yes

Keywords

dynamic contrast enhanced
initial area under the curve
magnetic resonance imaging
volume transfer constant

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/ima.22013

Cite this

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title = "In vivo correlation between semi-quantitative hemodynamic parameters and K trans derived from DCE-MRI of brain tumors",

abstract = "Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) has become more and more widely applied in cancer diagnosis and treatment follow-up. Without complicated calculation, a semiquantitative parameter - modified initial area under the curve (mIAUC c) - was proposed for better correlation with volume transfer constant (K trans) by computer simulation. In this study, we aim to further investigate the correlation between mIAUC c and K trans in clinical. A total of 10 patients with brain tumors participated in this study and images were acquired by using a 3-Tesla clinical MR scanner. The results showed that mIAUC c was highly correlated with K trans with the correlation coefficient of 0.913. Although the ideals of K trans and mIAUC c are different, mIAUC c does the trick for brain tumors evaluations in DCE-MRI. It reveals that mIAUC c could be an alternative for physiological condition evaluation in DCE-MRI.",

keywords = "dynamic contrast enhanced, initial area under the curve, magnetic resonance imaging, volume transfer constant",

author = "Chen, \{Chih Feng\} and Hsu, \{Ling Wei\} and Lui, \{Chun Chung\} and Lee, \{Chen Chang\} and Weng, \{Hsu Huei\} and Tsai, \{Yuan Hsiung\} and Liu, \{Ho Ling\}",

year = "2012",

month = jun,

doi = "10.1002/ima.22013",

language = "英语",

volume = "22",

pages = "132--136",

journal = "International Journal of Imaging Systems and Technology",

issn = "0899-9457",

publisher = "John Wiley and Sons Inc",

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}

TY - JOUR

T1 - In vivo correlation between semi-quantitative hemodynamic parameters and K trans derived from DCE-MRI of brain tumors

AU - Chen, Chih Feng

AU - Hsu, Ling Wei

AU - Lui, Chun Chung

AU - Lee, Chen Chang

AU - Weng, Hsu Huei

AU - Tsai, Yuan Hsiung

AU - Liu, Ho Ling

PY - 2012/6

Y1 - 2012/6

N2 - Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) has become more and more widely applied in cancer diagnosis and treatment follow-up. Without complicated calculation, a semiquantitative parameter - modified initial area under the curve (mIAUC c) - was proposed for better correlation with volume transfer constant (K trans) by computer simulation. In this study, we aim to further investigate the correlation between mIAUC c and K trans in clinical. A total of 10 patients with brain tumors participated in this study and images were acquired by using a 3-Tesla clinical MR scanner. The results showed that mIAUC c was highly correlated with K trans with the correlation coefficient of 0.913. Although the ideals of K trans and mIAUC c are different, mIAUC c does the trick for brain tumors evaluations in DCE-MRI. It reveals that mIAUC c could be an alternative for physiological condition evaluation in DCE-MRI.

AB - Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) has become more and more widely applied in cancer diagnosis and treatment follow-up. Without complicated calculation, a semiquantitative parameter - modified initial area under the curve (mIAUC c) - was proposed for better correlation with volume transfer constant (K trans) by computer simulation. In this study, we aim to further investigate the correlation between mIAUC c and K trans in clinical. A total of 10 patients with brain tumors participated in this study and images were acquired by using a 3-Tesla clinical MR scanner. The results showed that mIAUC c was highly correlated with K trans with the correlation coefficient of 0.913. Although the ideals of K trans and mIAUC c are different, mIAUC c does the trick for brain tumors evaluations in DCE-MRI. It reveals that mIAUC c could be an alternative for physiological condition evaluation in DCE-MRI.

KW - dynamic contrast enhanced

KW - initial area under the curve

KW - magnetic resonance imaging

KW - volume transfer constant

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DO - 10.1002/ima.22013

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