Abstract
BACKGROUND: Tau pathology is observed during autopsy in many patients with Parkinson's disease dementia (PDD). Positron emission tomography (PET) imaging using the tracer 18 F-florzolotau has the potential to capture tau accumulation in the living brain.
OBJECTIVE: The aim was to describe the results of 18 F-florzolotau PET/CT (computed tomography) imaging in patients with PDD.
METHODS: Ten patients with PDD, 9 with Parkinson's disease with normal cognition (PD-NC), and 9 age-matched healthy controls (HCs) were enrolled. Clinical assessments and 18 F-florzolotau PET/CT imaging were performed.
RESULTS: 18 F-Florzolotau uptake was significantly higher in the cortical regions of patients with PDD compared with both PD-NC and HCs, especially in the temporal lobe. Notably, 18 F-florzolotau uptake in the occipital lobe of patients with PDD showed a significant correlation with cognitive impairment as reflected by Mini-Mental State Examination (MMSE) scores.
CONCLUSIONS: 18 F-Florzolotau PET imaging can effectively capture the occurrence of tau pathology in patients with PDD, which was also linked to MMSE scores. © 2022 International Parkinson and Movement Disorder Society.
| Original language | English |
|---|---|
| Pages (from-to) | 147-152 |
| Number of pages | 6 |
| Journal | Movement Disorders |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| State | Published - 01 2023 |
Bibliographical note
© 2022 International Parkinson and Movement Disorder Society.Keywords
- F-florzolotau
- Parkinson's disease dementia
- tau PET imaging
- Parkinson Disease/diagnostic imaging
- Positron Emission Tomography Computed Tomography
- Dementia/diagnostic imaging
- Humans
- Alzheimer Disease
- Positron-Emission Tomography/methods
- tau Proteins