Incidence of needle tract seeding and responses of soft tissue metastasis by hepatocellular carcinoma postradiotherapy

Wei Chih Tung; Yu Jie Huang; Stephen Wan Leung; Fang Ying Kuo; Hung Da Tung; Jing Houng Wang; Chao Hung Hung; Chuan Mo Lee; Chi Sin Changchien; Shih An Yeh; Li Min Sun; Eng Yen Huang; Hsuan Chih Hsu; Chong Jong Wang; Sheng Nan Lu

doi:10.1111/j.1478-3231.2006.01399.x

Incidence of needle tract seeding and responses of soft tissue metastasis by hepatocellular carcinoma postradiotherapy

Wei Chih Tung, Yu Jie Huang, Stephen Wan Leung, Fang Ying Kuo, Hung Da Tung, Jing Houng Wang, Chao Hung Hung, Chuan Mo Lee, Chi Sin Changchien, Shih An Yeh, Li Min Sun, Eng Yen Huang, Hsuan Chih Hsu, Chong Jong Wang, Sheng Nan Lu^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

45 Scopus citations

Abstract

Aim: To determine the incidence of needle tract seeding after fine needle aspiration (FNA) or percutaneous ethanol injection (PEI) and compare iatrogenic or spontaneous soft tissue metastasis (STM) by hepatocellular carcinoma (HCC) postradiotherapy (RT) in responses. Methods: From November 1997 to January 2006, those who presented with STM by HCC after our invasive procedures or developed spontaneously were enrolled into this retrospective study. Metastatic lesions could be divided into procedure related (PR), which were located at the liver span and were related to invasive procedures, and non-procedure related (NPR), which were in extrahepatic areas. STM was treated with an electron or photon beam. Results: A total of 39 HCC cases with developed STM were referred for RT, including 17 in the PR group and 22 in the NPR group. During the same period, a total of 18 227 person-times of FNA or PEI were performed on these HCC patients. The overall incidence of HCC with STM that was caused by invasive procedures was estimated at 0.13%. According to the Cox' regression model, the initial treatment modality influences the time duration after the initial diagnosis of HCC when STM has not occurred. None of these patients' soft tissue tumor increased in size during RT. The PR group had lower rates of bone metastasis (P = 0.003) and coexisting extrahepatic metastasis (P = 0.011) and a longer survival rate (P = 0.003) than the NPR group. The estimated rates of 18-gauge and 22-gauge needle-induced HCC-related STM were 0.60% and 0.11%, respectively (P = 0.064). Conclusion: The PR group bears a better prognosis than the NPR group post-RT.

Original language	English
Pages (from-to)	192-200
Number of pages	9
Journal	Liver International
Volume	27
Issue number	2
DOIs	https://doi.org/10.1111/j.1478-3231.2006.01399.x
State	Published - 03 2007

Keywords

Hepatocellular carcinoma
Needle tract seeding
Percutaneous ethanol injection
Radiotherapy
Soft tissue metastasis

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10.1111/j.1478-3231.2006.01399.x

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Tung, W. C., Huang, Y. J., Leung, S. W., Kuo, F. Y., Tung, H. D., Wang, J. H., Hung, C. H., Lee, C. M., Changchien, C. S., Yeh, S. A., Sun, L. M., Huang, E. Y., Hsu, H. C., Wang, C. J., & Lu, S. N. (2007). Incidence of needle tract seeding and responses of soft tissue metastasis by hepatocellular carcinoma postradiotherapy. Liver International, 27(2), 192-200. https://doi.org/10.1111/j.1478-3231.2006.01399.x

@article{2c34cb2e863d4207850af8ffff82fedc,

title = "Incidence of needle tract seeding and responses of soft tissue metastasis by hepatocellular carcinoma postradiotherapy",

abstract = "Aim: To determine the incidence of needle tract seeding after fine needle aspiration (FNA) or percutaneous ethanol injection (PEI) and compare iatrogenic or spontaneous soft tissue metastasis (STM) by hepatocellular carcinoma (HCC) postradiotherapy (RT) in responses. Methods: From November 1997 to January 2006, those who presented with STM by HCC after our invasive procedures or developed spontaneously were enrolled into this retrospective study. Metastatic lesions could be divided into procedure related (PR), which were located at the liver span and were related to invasive procedures, and non-procedure related (NPR), which were in extrahepatic areas. STM was treated with an electron or photon beam. Results: A total of 39 HCC cases with developed STM were referred for RT, including 17 in the PR group and 22 in the NPR group. During the same period, a total of 18 227 person-times of FNA or PEI were performed on these HCC patients. The overall incidence of HCC with STM that was caused by invasive procedures was estimated at 0.13%. According to the Cox' regression model, the initial treatment modality influences the time duration after the initial diagnosis of HCC when STM has not occurred. None of these patients' soft tissue tumor increased in size during RT. The PR group had lower rates of bone metastasis (P = 0.003) and coexisting extrahepatic metastasis (P = 0.011) and a longer survival rate (P = 0.003) than the NPR group. The estimated rates of 18-gauge and 22-gauge needle-induced HCC-related STM were 0.60% and 0.11%, respectively (P = 0.064). Conclusion: The PR group bears a better prognosis than the NPR group post-RT.",

keywords = "Hepatocellular carcinoma, Needle tract seeding, Percutaneous ethanol injection, Radiotherapy, Soft tissue metastasis",

author = "Tung, {Wei Chih} and Huang, {Yu Jie} and Leung, {Stephen Wan} and Kuo, {Fang Ying} and Tung, {Hung Da} and Wang, {Jing Houng} and Hung, {Chao Hung} and Lee, {Chuan Mo} and Changchien, {Chi Sin} and Yeh, {Shih An} and Sun, {Li Min} and Huang, {Eng Yen} and Hsu, {Hsuan Chih} and Wang, {Chong Jong} and Lu, {Sheng Nan}",

year = "2007",

month = mar,

doi = "10.1111/j.1478-3231.2006.01399.x",

language = "英语",

volume = "27",

pages = "192--200",

journal = "Liver International",

issn = "1478-3223",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "2",

}

Tung, WC, Huang, YJ, Leung, SW, Kuo, FY, Tung, HD, Wang, JH, Hung, CH, Lee, CM, Changchien, CS, Yeh, SA, Sun, LM, Huang, EY, Hsu, HC, Wang, CJ & Lu, SN 2007, 'Incidence of needle tract seeding and responses of soft tissue metastasis by hepatocellular carcinoma postradiotherapy', Liver International, vol. 27, no. 2, pp. 192-200. https://doi.org/10.1111/j.1478-3231.2006.01399.x

TY - JOUR

T1 - Incidence of needle tract seeding and responses of soft tissue metastasis by hepatocellular carcinoma postradiotherapy

AU - Tung, Wei Chih

AU - Huang, Yu Jie

AU - Leung, Stephen Wan

AU - Kuo, Fang Ying

AU - Tung, Hung Da

AU - Wang, Jing Houng

AU - Hung, Chao Hung

AU - Lee, Chuan Mo

AU - Changchien, Chi Sin

AU - Yeh, Shih An

AU - Sun, Li Min

AU - Huang, Eng Yen

AU - Hsu, Hsuan Chih

AU - Wang, Chong Jong

AU - Lu, Sheng Nan

PY - 2007/3

Y1 - 2007/3

N2 - Aim: To determine the incidence of needle tract seeding after fine needle aspiration (FNA) or percutaneous ethanol injection (PEI) and compare iatrogenic or spontaneous soft tissue metastasis (STM) by hepatocellular carcinoma (HCC) postradiotherapy (RT) in responses. Methods: From November 1997 to January 2006, those who presented with STM by HCC after our invasive procedures or developed spontaneously were enrolled into this retrospective study. Metastatic lesions could be divided into procedure related (PR), which were located at the liver span and were related to invasive procedures, and non-procedure related (NPR), which were in extrahepatic areas. STM was treated with an electron or photon beam. Results: A total of 39 HCC cases with developed STM were referred for RT, including 17 in the PR group and 22 in the NPR group. During the same period, a total of 18 227 person-times of FNA or PEI were performed on these HCC patients. The overall incidence of HCC with STM that was caused by invasive procedures was estimated at 0.13%. According to the Cox' regression model, the initial treatment modality influences the time duration after the initial diagnosis of HCC when STM has not occurred. None of these patients' soft tissue tumor increased in size during RT. The PR group had lower rates of bone metastasis (P = 0.003) and coexisting extrahepatic metastasis (P = 0.011) and a longer survival rate (P = 0.003) than the NPR group. The estimated rates of 18-gauge and 22-gauge needle-induced HCC-related STM were 0.60% and 0.11%, respectively (P = 0.064). Conclusion: The PR group bears a better prognosis than the NPR group post-RT.

AB - Aim: To determine the incidence of needle tract seeding after fine needle aspiration (FNA) or percutaneous ethanol injection (PEI) and compare iatrogenic or spontaneous soft tissue metastasis (STM) by hepatocellular carcinoma (HCC) postradiotherapy (RT) in responses. Methods: From November 1997 to January 2006, those who presented with STM by HCC after our invasive procedures or developed spontaneously were enrolled into this retrospective study. Metastatic lesions could be divided into procedure related (PR), which were located at the liver span and were related to invasive procedures, and non-procedure related (NPR), which were in extrahepatic areas. STM was treated with an electron or photon beam. Results: A total of 39 HCC cases with developed STM were referred for RT, including 17 in the PR group and 22 in the NPR group. During the same period, a total of 18 227 person-times of FNA or PEI were performed on these HCC patients. The overall incidence of HCC with STM that was caused by invasive procedures was estimated at 0.13%. According to the Cox' regression model, the initial treatment modality influences the time duration after the initial diagnosis of HCC when STM has not occurred. None of these patients' soft tissue tumor increased in size during RT. The PR group had lower rates of bone metastasis (P = 0.003) and coexisting extrahepatic metastasis (P = 0.011) and a longer survival rate (P = 0.003) than the NPR group. The estimated rates of 18-gauge and 22-gauge needle-induced HCC-related STM were 0.60% and 0.11%, respectively (P = 0.064). Conclusion: The PR group bears a better prognosis than the NPR group post-RT.

KW - Hepatocellular carcinoma

KW - Needle tract seeding

KW - Percutaneous ethanol injection

KW - Radiotherapy

KW - Soft tissue metastasis

UR - http://www.scopus.com/inward/record.url?scp=34247556509&partnerID=8YFLogxK

U2 - 10.1111/j.1478-3231.2006.01399.x

DO - 10.1111/j.1478-3231.2006.01399.x

M3 - 文章

C2 - 17311613

AN - SCOPUS:34247556509

SN - 1478-3223

VL - 27

SP - 192

EP - 200

JO - Liver International

JF - Liver International

IS - 2

ER -

Incidence of needle tract seeding and responses of soft tissue metastasis by hepatocellular carcinoma postradiotherapy

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