Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells

Shuyuan Yeh; Yueh Chiang Hu; Mujib Rahman; Hui Kuan Lin; Cheng Lung Hsu; Huei Ju Ting; Hong Yo Kang; Chawnshang Chang

doi:10.1073/pnas.190353897

Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells

Shuyuan Yeh, Yueh Chiang Hu, Mujib Rahman, Hui Kuan Lin, Cheng Lung Hsu, Huei Ju Ting, Hong Yo Kang, Chawnshang Chang^*

^*Corresponding author for this work

University of Rochester

Research output: Contribution to journal › Journal Article › peer-review

138 Scopus citations

Abstract

Although mutations of the breast cancer susceptibility gene 1 (BRCA1) may play important roles in breast and prostate cancers, the detailed mechanism linking the functions of BRCA1 to these two hormone-related tumors remains to be elucidated. Here, we report that BRCA1 interacts with androgen receptor (AR) and enhances AR target genes, such as p21((WAF1)/(CIP1)), that may result in the increase of androgen-induced cell death in prostate cancer cells. The BRCA1-enhanced AR transactivation can be further induced synergistically with AR coregulators, such as CBP, ARA55, and ARA70. Together, these data suggest that the BRCA1 may function as an AR coregulator and play positive roles in androgen-induced cell death in prostate cancer cells and other androgen/AR target organs.

Original language	English
Pages (from-to)	11256-11261
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	97
Issue number	21
DOIs	https://doi.org/10.1073/pnas.190353897
State	Published - 10 10 2000
Externally published	Yes

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10.1073/pnas.190353897

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@article{bc2a9d98249a4a64bbefd5bd4e3b063d,

title = "Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells",

abstract = "Although mutations of the breast cancer susceptibility gene 1 (BRCA1) may play important roles in breast and prostate cancers, the detailed mechanism linking the functions of BRCA1 to these two hormone-related tumors remains to be elucidated. Here, we report that BRCA1 interacts with androgen receptor (AR) and enhances AR target genes, such as p21((WAF1)/(CIP1)), that may result in the increase of androgen-induced cell death in prostate cancer cells. The BRCA1-enhanced AR transactivation can be further induced synergistically with AR coregulators, such as CBP, ARA55, and ARA70. Together, these data suggest that the BRCA1 may function as an AR coregulator and play positive roles in androgen-induced cell death in prostate cancer cells and other androgen/AR target organs.",

author = "Shuyuan Yeh and Hu, \{Yueh Chiang\} and Mujib Rahman and Lin, \{Hui Kuan\} and Hsu, \{Cheng Lung\} and Ting, \{Huei Ju\} and Kang, \{Hong Yo\} and Chawnshang Chang",

year = "2000",

month = oct,

day = "10",

doi = "10.1073/pnas.190353897",

language = "英语",

volume = "97",

pages = "11256--11261",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "21",

}

Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells. / Yeh, Shuyuan; Hu, Yueh Chiang; Rahman, Mujib et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 21, 10.10.2000, p. 11256-11261.

Research output: Contribution to journal › Journal Article › peer-review

TY - JOUR

T1 - Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells

AU - Yeh, Shuyuan

AU - Hu, Yueh Chiang

AU - Rahman, Mujib

AU - Lin, Hui Kuan

AU - Hsu, Cheng Lung

AU - Ting, Huei Ju

AU - Kang, Hong Yo

AU - Chang, Chawnshang

PY - 2000/10/10

Y1 - 2000/10/10

N2 - Although mutations of the breast cancer susceptibility gene 1 (BRCA1) may play important roles in breast and prostate cancers, the detailed mechanism linking the functions of BRCA1 to these two hormone-related tumors remains to be elucidated. Here, we report that BRCA1 interacts with androgen receptor (AR) and enhances AR target genes, such as p21((WAF1)/(CIP1)), that may result in the increase of androgen-induced cell death in prostate cancer cells. The BRCA1-enhanced AR transactivation can be further induced synergistically with AR coregulators, such as CBP, ARA55, and ARA70. Together, these data suggest that the BRCA1 may function as an AR coregulator and play positive roles in androgen-induced cell death in prostate cancer cells and other androgen/AR target organs.

AB - Although mutations of the breast cancer susceptibility gene 1 (BRCA1) may play important roles in breast and prostate cancers, the detailed mechanism linking the functions of BRCA1 to these two hormone-related tumors remains to be elucidated. Here, we report that BRCA1 interacts with androgen receptor (AR) and enhances AR target genes, such as p21((WAF1)/(CIP1)), that may result in the increase of androgen-induced cell death in prostate cancer cells. The BRCA1-enhanced AR transactivation can be further induced synergistically with AR coregulators, such as CBP, ARA55, and ARA70. Together, these data suggest that the BRCA1 may function as an AR coregulator and play positive roles in androgen-induced cell death in prostate cancer cells and other androgen/AR target organs.

UR - https://www.scopus.com/pages/publications/0034633661

U2 - 10.1073/pnas.190353897

DO - 10.1073/pnas.190353897

M3 - 文章

C2 - 11016951

AN - SCOPUS:0034633661

SN - 0027-8424

VL - 97

SP - 11256

EP - 11261

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 21

ER -

Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells

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