Increased autophagy in the placental territory of selective intrauterine growth-restricted monochorionic twins

Yao Lung Chang, Tzu Hao Wang, Shuenn Dyh Chang, An Shine Chao, Peter C.C. Hsieh, Chao Nin Wang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

14 Scopus citations


Subject: This study investigates the placental autophagic activity in growth-restricted fetuses in the monochorionic (MC) twin model. Patients and methods: Forty MC twins were prospectively enrolled in this study, including 21 with and 19 without selective intrauterine growth restriction (sIUGR), defined as birth weight below the tenth percentile. The sIUGR group was subdivided on the basis of present versus absent or reversed umbilical artery end-diastolic flow at Doppler. Placenta samples were taken after delivery from each twin placenta territories. After protein extraction, Western blot was used to determine light chain 3 (LC3)-II placental protein expression in sIUGR and appropriately grown (appropriate-for-gestational age, AGA) twins. Results: The LC3-II was significantly higher in the sIUGR twin placental territory than in their AGA counterparts. In the sIUGR group, LC3-II fold change was significantly increased compared with that in the AGA cotwins (2.28 vs 1.04, p<0.05). Placental LC3-II protein expression was particularly stimulated in the MC sIUGR group with abnormal umbilical artery Doppler flow compared with AGA controls (p<0.05, one-way analysis of variance test). Conclusions: In MC twins, the placental autophagic activity is different between sIUGR and AGA cotwins. The placenta territory with the least blood flow perfusion has the highest autophagic activity.

Original languageEnglish
Pages (from-to)187-190
Number of pages4
JournalPrenatal Diagnosis
Issue number2
StatePublished - 02 2013


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