Increased Dose and Duration of Statin Use Is Associated with Decreased Asthma-Related Emergency Department Visits and Hospitalizations

Jiu Yao Wang, Tsung Chieh Yao, Yu Ting Tsai, Ann Chen Wu*, Hui Ju Tsai

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

27 Scopus citations

Abstract

Background: Statins have pleiotropic anti-inflammatory and immunomodulatory effects, yet the effect of statin use on asthma-related emergency department (ED) visits and hospitalizations has remained unclear, especially in Asian populations. Objective: We sought to examine the effect of statin therapy on asthma-related ED visits and/or hospitalizations. Methods: A cohort study was conducted using data from Taiwan's National Health Insurance Research Database from 2001 to 2013. A total of 117,595 adult patients with asthma were included. The outcomes were defined as asthma-related ED visits and/or hospitalizations. Multiple Cox proportional hazards models were applied to determine the effect of statin use on asthma-related ED visits and/or hospitalizations. Results: There were 3,417 asthma-related ED visits and/or hospitalizations among 117,595 subjects with asthma. Statin users were significantly less likely to experience asthma-related ED visits and/or hospitalizations (adjusted hazard ratio: 0.81; 95% confidence interval: 0.74-0.89) compared with nonstatin users. The risks of asthma-related ED visits and/or hospitalizations were decreased among those with a higher cumulative defined daily dose (DDD), greater average DDD, and longer cumulative-day users than the counterparts. Conclusions: Our study suggests that statin use is associated with the decreased risk of asthma-related ED visits and/or hospitalizations in patients with asthma. A dose-response effect of statin use is also observed in this study. Therefore, future randomized clinical trials would be warranted to further evaluate the association.

Original languageEnglish
Pages (from-to)1588-1595.e1
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume6
Issue number5
DOIs
StatePublished - 01 09 2018

Bibliographical note

Publisher Copyright:
© 2018 American Academy of Allergy, Asthma & Immunology

Keywords

  • Adulthood asthma
  • Asthma exacerbation
  • Statin

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