TY - JOUR
T1 - Independent determinants of coronary artery disease in erectile dysfunction patients
AU - Chang, Shih Tai
AU - Chu, Chi Ming
AU - Hsu, Jen Te
AU - Hsiao, Ju Feng
AU - Chung, Chang Min
AU - Ho, Cheng
AU - Peng, Yun Shing
AU - Chen, Pao Yin
AU - Shee, Jia Jen
PY - 2010/4
Y1 - 2010/4
N2 - Introduction.: There is growing evidence of a link between erectile dysfunction (ED) and coronary artery disease (CAD). Aims.: The purpose of this study was to explore the independent determinants of CAD in ED outpatients. Methods.: This study enrolled 243 patients, ranging in age from 21 to 81 years old, suffering from ED as diagnosed by the International Index of Erectile Function (IIEF) scores. All patients underwent exercise stress tests or thallium-201 single-photon emission computed tomography perfusion imagings. Based on examination results, patients were divided into study (22 patients with a positive finding) and control groups (221 patients with a negative finding). Main Outcome Measures.: The differences of demographic characteristics, biochemical profiles, pro-inflammatory and inflammatory markers, and echocardiographic characteristics between study and control group were compared. Results.: The age, presence of DM and current smoking status were significant high in the study group. A significant lower high-density lipoprotein (HDL) cholesterol level, a higher percentage of HDL cholesterol level < 40 mg/dL, and a higher apo-lipoprotein B/A1, high sensitive C-reactive protein (hs-CRP) and homocysteine found in the study group. The Framingham cardiac risk scores, the ratio of mitral inflow velocity to early diastolic velocity in the annulus derived by tissue Doppler imaging (E/Et), the ratio of E/Et ≥ 15, the value of carotid intima-media thickness (IMT), and IMT ≥ 1 mm were higher in study group than in the control group. In stepwise multiple logistic regression analysis, a high waist-to-hip ratio (WHR), high IMT, high E/Et, hs-CRP levels, LDL cholesterol ≥ 130 mg/dL, smoking status, and the presence of DM and metabolic syndrome (MS) were independent determinants of CAD in ED patients. Conclusions.: This study first shows the independent determinants of CAD in ED outpatients. This novel finding may improve the screening of low-risk ED patients for CAD. Chang S-T, Chu C-M, Hsu J-T, Hsiao J-F, Chung C-M, Ho C, Peng Y-S, Chen P-Y, and Shee J-J. Independent determinants of coronary artery disease in erectile dysfunction patients.
AB - Introduction.: There is growing evidence of a link between erectile dysfunction (ED) and coronary artery disease (CAD). Aims.: The purpose of this study was to explore the independent determinants of CAD in ED outpatients. Methods.: This study enrolled 243 patients, ranging in age from 21 to 81 years old, suffering from ED as diagnosed by the International Index of Erectile Function (IIEF) scores. All patients underwent exercise stress tests or thallium-201 single-photon emission computed tomography perfusion imagings. Based on examination results, patients were divided into study (22 patients with a positive finding) and control groups (221 patients with a negative finding). Main Outcome Measures.: The differences of demographic characteristics, biochemical profiles, pro-inflammatory and inflammatory markers, and echocardiographic characteristics between study and control group were compared. Results.: The age, presence of DM and current smoking status were significant high in the study group. A significant lower high-density lipoprotein (HDL) cholesterol level, a higher percentage of HDL cholesterol level < 40 mg/dL, and a higher apo-lipoprotein B/A1, high sensitive C-reactive protein (hs-CRP) and homocysteine found in the study group. The Framingham cardiac risk scores, the ratio of mitral inflow velocity to early diastolic velocity in the annulus derived by tissue Doppler imaging (E/Et), the ratio of E/Et ≥ 15, the value of carotid intima-media thickness (IMT), and IMT ≥ 1 mm were higher in study group than in the control group. In stepwise multiple logistic regression analysis, a high waist-to-hip ratio (WHR), high IMT, high E/Et, hs-CRP levels, LDL cholesterol ≥ 130 mg/dL, smoking status, and the presence of DM and metabolic syndrome (MS) were independent determinants of CAD in ED patients. Conclusions.: This study first shows the independent determinants of CAD in ED outpatients. This novel finding may improve the screening of low-risk ED patients for CAD. Chang S-T, Chu C-M, Hsu J-T, Hsiao J-F, Chung C-M, Ho C, Peng Y-S, Chen P-Y, and Shee J-J. Independent determinants of coronary artery disease in erectile dysfunction patients.
KW - Cardiovascular Risk Factors for Erectile Dysfunction
KW - Coronary Artery Disease
KW - Erectile Dysfunction
KW - Inflammatory Marker
KW - Metabolic Syndrome
KW - Obesity
UR - https://www.scopus.com/pages/publications/77955258803
U2 - 10.1111/j.1743-6109.2009.01562.x
DO - 10.1111/j.1743-6109.2009.01562.x
M3 - 文章
C2 - 19878446
AN - SCOPUS:77955258803
SN - 1743-6095
VL - 7
SP - 1478
EP - 1487
JO - Journal of Sexual Medicine
JF - Journal of Sexual Medicine
IS - 4 PART 1
ER -
