Indigodole E from Strobilanthes cusia exhibits anti-IL-17A effect

Chia Lin Lee; Chien Ming Wang; Hung Rong Yen; Ying Chyi Song; Chao Jung Chen

doi:10.1080/14786419.2022.2041633

Indigodole E from Strobilanthes cusia exhibits anti-IL-17A effect

Chia Lin Lee^*, Chien Ming Wang, Hung Rong Yen, Ying Chyi Song, Chao Jung Chen

^*Corresponding author for this work

China Medical University Taichung

Research output: Contribution to journal › Journal Article › peer-review

2 Scopus citations

Abstract

One new indazole alkaloid, indigodole E (1), was isolated from a traditional Chinese medicine Qing Dai prepared from the aerial parts of Strobilanthes cusia. The structure of 1 was elucidated by NMR, MS, UV, and IR spectra as well as optical rotation. Additionally, compound 1 could obviously inhibit not only IL-17A protein production at concentrations from 1.25 to 2.5 μg/mL, but also IL-17 gene expression at concentrations from 5.0 to 10.0 μg/mL without cytotoxicity toward Th17 and Jukat cells, respectively. Overall, indazole analogue 1 could be the anti-IL 17 A contributor of Qing Dai in this investigation.

Original language	English
Pages (from-to)	5935-5939
Number of pages	5
Journal	Natural Product Research
Volume	36
Issue number	23
DOIs	https://doi.org/10.1080/14786419.2022.2041633
State	Published - 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

Acanthaceae
IL-17A inhibition
Qing Dai
Strobilanthes cusia
indazole alkaloid
indigodole E

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10.1080/14786419.2022.2041633

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title = "Indigodole E from Strobilanthes cusia exhibits anti-IL-17A effect",

abstract = "One new indazole alkaloid, indigodole E (1), was isolated from a traditional Chinese medicine Qing Dai prepared from the aerial parts of Strobilanthes cusia. The structure of 1 was elucidated by NMR, MS, UV, and IR spectra as well as optical rotation. Additionally, compound 1 could obviously inhibit not only IL-17A protein production at concentrations from 1.25 to 2.5 μg/mL, but also IL-17 gene expression at concentrations from 5.0 to 10.0 μg/mL without cytotoxicity toward Th17 and Jukat cells, respectively. Overall, indazole analogue 1 could be the anti-IL 17 A contributor of Qing Dai in this investigation.",

keywords = "Acanthaceae, IL-17A inhibition, Qing Dai, Strobilanthes cusia, indazole alkaloid, indigodole E",

author = "Lee, {Chia Lin} and Wang, {Chien Ming} and Yen, {Hung Rong} and Song, {Ying Chyi} and Chen, {Chao Jung}",

note = "Publisher Copyright: {\textcopyright} 2022 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2022",

doi = "10.1080/14786419.2022.2041633",

language = "英语",

volume = "36",

pages = "5935--5939",

journal = "Natural Product Research",

issn = "1478-6419",

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T1 - Indigodole E from Strobilanthes cusia exhibits anti-IL-17A effect

AU - Lee, Chia Lin

AU - Wang, Chien Ming

AU - Yen, Hung Rong

AU - Song, Ying Chyi

AU - Chen, Chao Jung

PY - 2022

Y1 - 2022

N2 - One new indazole alkaloid, indigodole E (1), was isolated from a traditional Chinese medicine Qing Dai prepared from the aerial parts of Strobilanthes cusia. The structure of 1 was elucidated by NMR, MS, UV, and IR spectra as well as optical rotation. Additionally, compound 1 could obviously inhibit not only IL-17A protein production at concentrations from 1.25 to 2.5 μg/mL, but also IL-17 gene expression at concentrations from 5.0 to 10.0 μg/mL without cytotoxicity toward Th17 and Jukat cells, respectively. Overall, indazole analogue 1 could be the anti-IL 17 A contributor of Qing Dai in this investigation.

AB - One new indazole alkaloid, indigodole E (1), was isolated from a traditional Chinese medicine Qing Dai prepared from the aerial parts of Strobilanthes cusia. The structure of 1 was elucidated by NMR, MS, UV, and IR spectra as well as optical rotation. Additionally, compound 1 could obviously inhibit not only IL-17A protein production at concentrations from 1.25 to 2.5 μg/mL, but also IL-17 gene expression at concentrations from 5.0 to 10.0 μg/mL without cytotoxicity toward Th17 and Jukat cells, respectively. Overall, indazole analogue 1 could be the anti-IL 17 A contributor of Qing Dai in this investigation.

KW - Acanthaceae

KW - IL-17A inhibition

KW - Qing Dai

KW - Strobilanthes cusia

KW - indazole alkaloid

KW - indigodole E

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DO - 10.1080/14786419.2022.2041633

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AN - SCOPUS:85125413254

SN - 1478-6419

VL - 36

SP - 5935

EP - 5939

JO - Natural Product Research

JF - Natural Product Research

IS - 23

ER -

Indigodole E from Strobilanthes cusia exhibits anti-IL-17A effect

Abstract

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