Indole alkaloids indigodoles A–C from aerial parts of Strobilanthes cusia in the traditional Chinese medicine Qing Dai have anti-IL-17 properties

Chia Lin Lee*, Chien Ming Wang, Hao Chun Hu, Hung Rong Yen, Ying Chyi Song, Sheng Jie Yu, Chao Jung Chen, Wei Chu Li, Yang Chang Wu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

39 Scopus citations

Abstract

Qing Dai (Naturalis Indigo) is a traditional Chinese medicine (TCM) used as a topical agent in moderate psoriasis, targeting interleukin-17 (IL-17). In this study, it was prepared from the aerial parts of Strobilanthes cusia. Three undescribed indole alkaloid derivatives, indigodoles A–C, along with seven known compounds were isolated from this preparation of Qing Dai and their structures were elucidated from spectroscopic data, including NMR, MS, UV, IR, optical rotation, and CD. As well, most compounds were tested against IL-17. Indigodole C and tryptanthrin could significantly inhibit IL-17 production of Th17 cells. In addition, indigodole A and indirubin showed notably anti-IL-17 gene expression in dose-dependent effects without cytotoxicities toward Th17 and Jurkat cells, respectively. Overall, our studies indicate that the aforementioned indole alkaloids could contribute to anti-IL 17 properties of Qing Dai.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalPhytochemistry
Volume162
DOIs
StatePublished - 06 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

  • Anti-IL 17 activities
  • Indigodoles A–C
  • Indole alkaloids
  • Psoriasis
  • Qing dai (Naturalis indigo)
  • Strobilanthes cusia (Acanthaceae)

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