Induction of ferroptosis and apoptosis in endometrial cancer cells by dihydroisotanshinone I

Ching Yuan Wu; Yao Hsu Yang; Yu Shih Lin; Li Hsin Shu; Hung Te Liu; Yu Huei Wu; Yu Heng Wu

doi:10.1016/j.heliyon.2023.e21652

Induction of ferroptosis and apoptosis in endometrial cancer cells by dihydroisotanshinone I

Ching Yuan Wu^*, Yao Hsu Yang, Yu Shih Lin, Li Hsin Shu, Hung Te Liu, Yu Huei Wu, Yu Heng Wu

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

2 Scopus citations

Abstract

Danshen, also known as Salvia miltiorrhiza, is a medicinal herb used in traditional Chinese medicine. Its potential impact on endometrial cancer has not been thoroughly investigated. This study aimed to examine the effect of dihydroisotanshinone I (DT), a compound found in Danshen, on the viability of ARK1 and ARK2 endometrial cancer cells and its mechanisms. The results showed that 10 μM DT inhibited cell viability of ARK1 and ARK2 cells by inducing apoptosis and ferroptosis, which was achieved by blocking the expression of GPX4. In vivo experiments using a xenograft nude mouse model indicated that DT treatment significantly reduced tumor volume without causing any adverse effects. These findings suggest that DT may be a potential therapeutic agent for inhibiting endometrial cancer cell viability, but further research is needed to confirm these results.

Original language	English
Article number	e21652
Journal	Heliyon
Volume	9
Issue number	11
DOIs	https://doi.org/10.1016/j.heliyon.2023.e21652
State	Published - 11 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors

Keywords

apoptosis
Dihydroisotanshinone I
Endometrial cancer
ferroptosis
GPX4

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.heliyon.2023.e21652

Cite this

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title = "Induction of ferroptosis and apoptosis in endometrial cancer cells by dihydroisotanshinone I",

abstract = "Danshen, also known as Salvia miltiorrhiza, is a medicinal herb used in traditional Chinese medicine. Its potential impact on endometrial cancer has not been thoroughly investigated. This study aimed to examine the effect of dihydroisotanshinone I (DT), a compound found in Danshen, on the viability of ARK1 and ARK2 endometrial cancer cells and its mechanisms. The results showed that 10 μM DT inhibited cell viability of ARK1 and ARK2 cells by inducing apoptosis and ferroptosis, which was achieved by blocking the expression of GPX4. In vivo experiments using a xenograft nude mouse model indicated that DT treatment significantly reduced tumor volume without causing any adverse effects. These findings suggest that DT may be a potential therapeutic agent for inhibiting endometrial cancer cell viability, but further research is needed to confirm these results.",

keywords = "apoptosis, Dihydroisotanshinone I, Endometrial cancer, ferroptosis, GPX4",

author = "Wu, {Ching Yuan} and Yang, {Yao Hsu} and Lin, {Yu Shih} and Shu, {Li Hsin} and Liu, {Hung Te} and Wu, {Yu Huei} and Wu, {Yu Heng}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = nov,

doi = "10.1016/j.heliyon.2023.e21652",

language = "英语",

volume = "9",

journal = "Heliyon",

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}

TY - JOUR

T1 - Induction of ferroptosis and apoptosis in endometrial cancer cells by dihydroisotanshinone I

AU - Wu, Ching Yuan

AU - Yang, Yao Hsu

AU - Lin, Yu Shih

AU - Shu, Li Hsin

AU - Liu, Hung Te

AU - Wu, Yu Huei

AU - Wu, Yu Heng

PY - 2023/11

Y1 - 2023/11

N2 - Danshen, also known as Salvia miltiorrhiza, is a medicinal herb used in traditional Chinese medicine. Its potential impact on endometrial cancer has not been thoroughly investigated. This study aimed to examine the effect of dihydroisotanshinone I (DT), a compound found in Danshen, on the viability of ARK1 and ARK2 endometrial cancer cells and its mechanisms. The results showed that 10 μM DT inhibited cell viability of ARK1 and ARK2 cells by inducing apoptosis and ferroptosis, which was achieved by blocking the expression of GPX4. In vivo experiments using a xenograft nude mouse model indicated that DT treatment significantly reduced tumor volume without causing any adverse effects. These findings suggest that DT may be a potential therapeutic agent for inhibiting endometrial cancer cell viability, but further research is needed to confirm these results.

AB - Danshen, also known as Salvia miltiorrhiza, is a medicinal herb used in traditional Chinese medicine. Its potential impact on endometrial cancer has not been thoroughly investigated. This study aimed to examine the effect of dihydroisotanshinone I (DT), a compound found in Danshen, on the viability of ARK1 and ARK2 endometrial cancer cells and its mechanisms. The results showed that 10 μM DT inhibited cell viability of ARK1 and ARK2 cells by inducing apoptosis and ferroptosis, which was achieved by blocking the expression of GPX4. In vivo experiments using a xenograft nude mouse model indicated that DT treatment significantly reduced tumor volume without causing any adverse effects. These findings suggest that DT may be a potential therapeutic agent for inhibiting endometrial cancer cell viability, but further research is needed to confirm these results.

KW - apoptosis

KW - Dihydroisotanshinone I

KW - Endometrial cancer

KW - ferroptosis

KW - GPX4

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U2 - 10.1016/j.heliyon.2023.e21652

DO - 10.1016/j.heliyon.2023.e21652

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AN - SCOPUS:85175442640

SN - 2405-8440

VL - 9

JO - Heliyon

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IS - 11

M1 - e21652

ER -

Induction of ferroptosis and apoptosis in endometrial cancer cells by dihydroisotanshinone I

Abstract

Bibliographical note

Keywords

UN SDGs

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