Influence of CETP gene variation on plasma lipid levels and coronary heart disease: A survey in Taiwan

June Hsieh Wu*, Yuan Teh Lee, Hsiu Ching Hsu, Ling Ling Hsieh

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

46 Scopus citations


Cholesteryl ester transfer protein (CETP) transfers cholesteryl ester from high-density lipoprotein (HDL) to very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and chylomicron in exchange for triglycerides. Two CETP genetic variation and four polymorphisms are investigated by polymerase chain reaction (PCR) and restriction enzyme digestion in a population of Taiwan. The results show that a very rare variation frequency is found for CETP intron 14 splice site G→A change. The population shows a predominant 405Ile allele (61%), 442Asp (97.7%), intron 1Taq1B+ G allele (52%), intron 8 Msp1- A allele (89%) and intron 9 EcoN1- T allele (59.2%) in the control group. Patients with coronary heart disease (CHD) have more CETP EcoN1+/+ GG genotype (25.3%) than the controls (13.6%) (P = 0.049). The intron 1 Taq1B- A allele is associated with a high HDL cholesterol and apoA1 level, the EcoN1+ G allele with a low apoA1 level and the 442Gly with both high total cholesterol and LDL cholesterol levels. Paradoxically, the 442Gly is also present with a higher frequency (5.2%) in HDL cholesterol ≥ 65 mg/dl group than that in the general population (2.3%) (P = 0.04).

Original languageEnglish
Pages (from-to)451-458
Number of pages8
Issue number2
StatePublished - 2001


  • CETP
  • Frequency distribution
  • Genetic mutation
  • Genetic polymorphism
  • HDL
  • Taiwanese population


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