Influence of controlled hypotension by adenosine triphosphate or nitroglycerin on the neuromuscular blocking effect of atracurium in dogs

Kwok Hon Chan*, Wui Chiu Mui, Min Wen Yang, Tak Yu Lee

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

3 Scopus citations

Abstract

The neuromuscular blocking effect of atracurium under the influence of controlled hypotension by adenosine triphosphate (ATP) or nitroglycerine (NTG) was studied in mongrel dogs under halothane anesthesia. Under hypotensive state (60 ± 5 mmHg) elicited by ATP (0.5 mg/kg/min) or NTG (1 μg/kg/min), the neuromuscular blockade produced by atracurium (30 μg/kg, i.v.) was significantly potentiated and prolonged. The maximal depression of twitch contraction of the gastrocnemius-soleus muscle increased from 10 ± 3% to 36 ± 10% (ATP group) and 56.0 ± 2.4% (NTG group), while the duration of neuromuscular blockade was prolonged from 663 ± 96 s to 1060 ± 277 s (ATP group), and 1375 ± 441 s (NTG group). The potentiation and prolongation of neuromuscular blockade by atracurium was still apparent upon reversal of the hypotensive effect of ATP, but not of NTG, by dopamine infusion. We suggest that ATP may prolong and augment the effect of atracurium by reducing the presynaptic release of acetylcholine at the neuromuscular junction.

Original languageEnglish
Pages (from-to)226-228
Number of pages3
JournalNeuroscience Letters
Volume123
Issue number2
DOIs
StatePublished - 25 02 1991
Externally publishedYes

Keywords

  • Adenosine triphosphate
  • Atracurium
  • Controlled hypotension
  • Neuromuscular blockade
  • Nitroglycerin

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