Influence of electrical and chemical factors on transdermal iontophoretic delivery of three diclofenac salts

Jia You Fang; Ren Jiunn Wang; Yaw Bin Huang; Pao Chu Wu; Yi Hung Tsai

doi:10.1248/bpb.24.390

Influence of electrical and chemical factors on transdermal iontophoretic delivery of three diclofenac salts

Jia You Fang
, Ren Jiunn Wang
, Yaw Bin Huang
, Pao Chu Wu
, Yi Hung Tsai^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

11 Scopus citations

Abstract

The aim of this present study was to investigate the in vitro transdermal iontophoretic delivery of three diclofenac salts-diclofenac sodium (DFS), diclofenac potassium (DFP), and diclofenac diethylammonium (DFD). A series of physicochemical and electrical variables which might affect iontophoretic permeation of diclofenac salts was studied. Application of 0.3 mA/cm² current density significantly increased the transdermal flux of diclofenac salts as compared to passive transport. The iontophoretic enhancement increased in the order of DFS>DFP>DFD. The permeability coefficient of diclofenac salts all decreased with increasing donor concentration during iontophoresis. The addition of buffer ions and salt ions such as NaCI, KCI, and C₄H₁₂CIN reduced the permeation of diclofenac salts due to competition. However, this effect was lesser for DFD than for DFS and DFP. Comparing the various application modes of iontophoresis, the discontinuous on/off mode showed lower but more constant flux than the continuous mode.

Original language	English
Pages (from-to)	390-394
Number of pages	5
Journal	Biological and Pharmaceutical Bulletin
Volume	24
Issue number	4
DOIs	https://doi.org/10.1248/bpb.24.390
State	Published - 2001
Externally published	Yes

Keywords

Counterion
Diclofenac salt
Iontophoresis
Transdermal absorption

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title = "Influence of electrical and chemical factors on transdermal iontophoretic delivery of three diclofenac salts",

abstract = "The aim of this present study was to investigate the in vitro transdermal iontophoretic delivery of three diclofenac salts-diclofenac sodium (DFS), diclofenac potassium (DFP), and diclofenac diethylammonium (DFD). A series of physicochemical and electrical variables which might affect iontophoretic permeation of diclofenac salts was studied. Application of 0.3 mA/cm2 current density significantly increased the transdermal flux of diclofenac salts as compared to passive transport. The iontophoretic enhancement increased in the order of DFS>DFP>DFD. The permeability coefficient of diclofenac salts all decreased with increasing donor concentration during iontophoresis. The addition of buffer ions and salt ions such as NaCI, KCI, and C4H12CIN reduced the permeation of diclofenac salts due to competition. However, this effect was lesser for DFD than for DFS and DFP. Comparing the various application modes of iontophoresis, the discontinuous on/off mode showed lower but more constant flux than the continuous mode.",

keywords = "Counterion, Diclofenac salt, Iontophoresis, Transdermal absorption",

author = "Fang, \{Jia You\} and Wang, \{Ren Jiunn\} and Huang, \{Yaw Bin\} and Wu, \{Pao Chu\} and Tsai, \{Yi Hung\}",

year = "2001",

doi = "10.1248/bpb.24.390",

language = "英语",

volume = "24",

pages = "390--394",

journal = "Biological and Pharmaceutical Bulletin",

issn = "0918-6158",

publisher = "Pharmaceutical Society of Japan",

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TY - JOUR

T1 - Influence of electrical and chemical factors on transdermal iontophoretic delivery of three diclofenac salts

AU - Fang, Jia You

AU - Wang, Ren Jiunn

AU - Huang, Yaw Bin

AU - Wu, Pao Chu

AU - Tsai, Yi Hung

PY - 2001

Y1 - 2001

N2 - The aim of this present study was to investigate the in vitro transdermal iontophoretic delivery of three diclofenac salts-diclofenac sodium (DFS), diclofenac potassium (DFP), and diclofenac diethylammonium (DFD). A series of physicochemical and electrical variables which might affect iontophoretic permeation of diclofenac salts was studied. Application of 0.3 mA/cm2 current density significantly increased the transdermal flux of diclofenac salts as compared to passive transport. The iontophoretic enhancement increased in the order of DFS>DFP>DFD. The permeability coefficient of diclofenac salts all decreased with increasing donor concentration during iontophoresis. The addition of buffer ions and salt ions such as NaCI, KCI, and C4H12CIN reduced the permeation of diclofenac salts due to competition. However, this effect was lesser for DFD than for DFS and DFP. Comparing the various application modes of iontophoresis, the discontinuous on/off mode showed lower but more constant flux than the continuous mode.

AB - The aim of this present study was to investigate the in vitro transdermal iontophoretic delivery of three diclofenac salts-diclofenac sodium (DFS), diclofenac potassium (DFP), and diclofenac diethylammonium (DFD). A series of physicochemical and electrical variables which might affect iontophoretic permeation of diclofenac salts was studied. Application of 0.3 mA/cm2 current density significantly increased the transdermal flux of diclofenac salts as compared to passive transport. The iontophoretic enhancement increased in the order of DFS>DFP>DFD. The permeability coefficient of diclofenac salts all decreased with increasing donor concentration during iontophoresis. The addition of buffer ions and salt ions such as NaCI, KCI, and C4H12CIN reduced the permeation of diclofenac salts due to competition. However, this effect was lesser for DFD than for DFS and DFP. Comparing the various application modes of iontophoresis, the discontinuous on/off mode showed lower but more constant flux than the continuous mode.

KW - Counterion

KW - Diclofenac salt

KW - Iontophoresis

KW - Transdermal absorption

UR - https://www.scopus.com/pages/publications/0035038041

U2 - 10.1248/bpb.24.390

DO - 10.1248/bpb.24.390

M3 - 文章

C2 - 11305601

AN - SCOPUS:0035038041

SN - 0918-6158

VL - 24

SP - 390

EP - 394

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 4

ER -

Influence of electrical and chemical factors on transdermal iontophoretic delivery of three diclofenac salts

Abstract

Keywords

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