Influences of Psychotropic Drugs during Pregnancy on the Newborn

王 維蒂, Chia-Yih Liu, Yong-Yi Yang

Research output: Contribution to journalJournal Article peer-review

Abstract

     目的:治療患有精神疾病的懷孕婦女對精神科醫師來說是一大挑戰。由於精神症狀可能危害母體及胎兒健康,必須予以積極治療。另一方面,幾乎所有的精神科用藥都可能透過胎盤而對胎兒成長有所影響;如可能提高致畸胎率,或在新生兒出生時有藥物副作用及戒斷症狀的可能。方法:本研究採病歷回溯方式,分析八位於林口長庚醫學中心精神科病房生產之產婦紀錄、懷孕期間用藥經過及新生兒出生狀況。結果:六位屬精神分裂症,二位屬情感型精神疾病之躁期。六位產婦採自然產,二位採剖腹產。八位新生兒皆為足月產,無外觀及器官之明顯異常。出生體重、APGAR分數、餵食狀況及胎便皆正常。一位新生兒因黃疸接受照光治療,一位新生兒出現四肢顫抖及肌肉張力升高,疑似椎體外症候群。另二位新生兒一位出現低體溫另一位有短暫發紺,但上述症狀皆在觀察後自行改善。結論:本研究並未發現服用精神藥物之孕婦所生產的新生兒有明顯異常。
     Objective: The aim of this article is to assess the effects of psychotropics used during gestation on neonates. Methods: In this retrospective study, we analyzed the characteristics of eight women with psychiatric disorders who gave birth to their infants in our hospital and who had received psychiatric drug treatment during their pregnancy. Results: Six of these women were diagnosed as schizophrenice, while two had a diagnosis of bipolar disorder and mania. All newborns were full term. The birth body weights and APGAR score were all normal. One of the neonates received phototherapy due to hyperbilirubinemia. One newborn exhibited tremors in the four limbs and muscle tone increase 10 hours after birth; extrapyramidal syndrome was suspected. Hypothermia and transient cyanosis were noted in another two newborns. Most of the above conditions were self-limiting without specific treatment. Conclusion: This study found no major physical problems in newborns exposed to psychotropic agents during pregnancy.
Original languageAmerican English
Pages (from-to)61-67
Journal臺灣精神醫學
Volume14
Issue number4
StatePublished - 2000

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