Information Entropy and Its Applications

Po Hsiang Tsui*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Ultrasound is a first-line diagnostic tool for imaging many disease states. A number of statistical distributions have been proposed to describe ultrasound backscattering measured from tissues having different disease states. As an example, in this chapter we use nonalcoholic fatty liver disease (NAFLD), which is a critical health issue on a global scale, to demonstrate the capabilities of ultrasound to diagnose disease. Ultrasound interaction with the liver is typically characterized by scattering, which is quantified for the purpose of determining the degree of liver steatosis and fibrosis. Information entropy provides an insight into signal uncertainty. This concept allows for the analysis of backscattered statistics without considering the distribution of data or the statistical properties of ultrasound signals. In this chapter, we examined the background of NAFLD and the sources of scattering in the liver. The fundamentals of information entropy and an algorithmic scheme for ultrasound entropy imaging are then presented. Lastly, some examples of using ultrasound entropy imaging to grade hepatic steatosis and evaluate the risk of liver fibrosis in patients with significant hepatic steatosis are presented to illustrate future opportunities for clinical use.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages15
StatePublished - 2023

Publication series

NameAdvances in experimental medicine and biology
ISSN (Print)0065-2598

Bibliographical note

© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.


  • Backscattering
  • Fatty liver
  • Information entropy
  • Liver fibrosis
  • Nonalcoholic fatty liver disease
  • Signal uncertainty
  • Liver/pathology
  • Liver Cirrhosis/diagnostic imaging
  • Humans
  • Ultrasonography
  • Entropy
  • Non-alcoholic Fatty Liver Disease/pathology


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