Inherited human IRAK-4 deficiency: An update

Capucine Picard; Horst Von Bernuth; Cheng Lung Ku; Kun Yang; Anne Puel; Jean Laurent Casanova

doi:10.1007/s12026-007-0006-2

Inherited human IRAK-4 deficiency: An update

Capucine Picard^*, Horst Von Bernuth, Cheng Lung Ku, Kun Yang, Anne Puel, Jean Laurent Casanova

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

34 Scopus citations

Abstract

Interleukin-1 receptor-associated kinase-4 (IRAK-4), a member of the IRAK family, plays an essential role in Toll-like receptor- and IL-1 receptor-mediated signaling. We briefly review inherited human IRAK-4 deficiency, a recently described primary immunodeficiency leading to recurrent, invasive, pyogenic bacteria infection, and invasive pneumococcal disease in particular.

Original language	English
Pages (from-to)	347-352
Number of pages	6
Journal	Immunologic Research
Volume	38
Issue number	1-3
DOIs	https://doi.org/10.1007/s12026-007-0006-2
State	Published - 07 2007
Externally published	Yes

Keywords

Inflammation
Interleukin-1 receptors
NF-κB
Primary immunodeficiency
Streptococcus pneumoniae
Toll-like receptors
Tumor necrosis factor receptors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12026-007-0006-2

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title = "Inherited human IRAK-4 deficiency: An update",

abstract = "Interleukin-1 receptor-associated kinase-4 (IRAK-4), a member of the IRAK family, plays an essential role in Toll-like receptor- and IL-1 receptor-mediated signaling. We briefly review inherited human IRAK-4 deficiency, a recently described primary immunodeficiency leading to recurrent, invasive, pyogenic bacteria infection, and invasive pneumococcal disease in particular.",

keywords = "Inflammation, Interleukin-1 receptors, NF-κB, Primary immunodeficiency, Streptococcus pneumoniae, Toll-like receptors, Tumor necrosis factor receptors",

author = "Capucine Picard and {Von Bernuth}, Horst and Ku, {Cheng Lung} and Kun Yang and Anne Puel and Casanova, {Jean Laurent}",

year = "2007",

month = jul,

doi = "10.1007/s12026-007-0006-2",

language = "英语",

volume = "38",

pages = "347--352",

journal = "Immunologic Research",

issn = "0257-277X",

publisher = "Springer",

number = "1-3",

}

TY - JOUR

T1 - Inherited human IRAK-4 deficiency

T2 - An update

AU - Picard, Capucine

AU - Von Bernuth, Horst

AU - Ku, Cheng Lung

AU - Yang, Kun

AU - Puel, Anne

AU - Casanova, Jean Laurent

PY - 2007/7

Y1 - 2007/7

N2 - Interleukin-1 receptor-associated kinase-4 (IRAK-4), a member of the IRAK family, plays an essential role in Toll-like receptor- and IL-1 receptor-mediated signaling. We briefly review inherited human IRAK-4 deficiency, a recently described primary immunodeficiency leading to recurrent, invasive, pyogenic bacteria infection, and invasive pneumococcal disease in particular.

AB - Interleukin-1 receptor-associated kinase-4 (IRAK-4), a member of the IRAK family, plays an essential role in Toll-like receptor- and IL-1 receptor-mediated signaling. We briefly review inherited human IRAK-4 deficiency, a recently described primary immunodeficiency leading to recurrent, invasive, pyogenic bacteria infection, and invasive pneumococcal disease in particular.

KW - Inflammation

KW - Interleukin-1 receptors

KW - NF-κB

KW - Primary immunodeficiency

KW - Streptococcus pneumoniae

KW - Toll-like receptors

KW - Tumor necrosis factor receptors

UR - http://www.scopus.com/inward/record.url?scp=35348883595&partnerID=8YFLogxK

U2 - 10.1007/s12026-007-0006-2

DO - 10.1007/s12026-007-0006-2

M3 - 文章

C2 - 17917042

AN - SCOPUS:35348883595

SN - 0257-277X

VL - 38

SP - 347

EP - 352

JO - Immunologic Research

JF - Immunologic Research

IS - 1-3

ER -

Inherited human IRAK-4 deficiency: An update

Abstract

Keywords

UN SDGs

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