Inhibition of Escherichia coli-induced meningitis by carboxyfullerence

Nina Tsao, Puthuparampil P. Kanakamma, Tien Yau Luh, Chen Kung Chou, Huan Yao Lei*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

95 Scopus citations


The effect of a water-soluble malonic acid derivative of carboxyfullerence (C60) against Escherichia coli-induced meningitis was tested. C60 can protect the mice from E. coli-induced death in a dose- dependent manner. C60 administered intraperitoneally as late as 9 h after E. coli injection was still protective. The C60-treated mice had less tumor necrosis factor alpha and interleukin-1β production by staining of brain tissue compared to the levels of production for nontreated mice. The E. coli- induced increases in blood-brain barrier permeability and inflammatory neutrophilic infiltration were also inhibited. These data suggest that C60 is a potentially therapeutic agent for bacterial meningitis.

Original languageEnglish
Pages (from-to)2273-2277
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Issue number9
StatePublished - 09 1999
Externally publishedYes


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