Abstract
The effect of a water-soluble malonic acid derivative of carboxyfullerence (C60) against Escherichia coli-induced meningitis was tested. C60 can protect the mice from E. coli-induced death in a dose- dependent manner. C60 administered intraperitoneally as late as 9 h after E. coli injection was still protective. The C60-treated mice had less tumor necrosis factor alpha and interleukin-1β production by staining of brain tissue compared to the levels of production for nontreated mice. The E. coli- induced increases in blood-brain barrier permeability and inflammatory neutrophilic infiltration were also inhibited. These data suggest that C60 is a potentially therapeutic agent for bacterial meningitis.
Original language | English |
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Pages (from-to) | 2273-2277 |
Number of pages | 5 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 43 |
Issue number | 9 |
DOIs | |
State | Published - 09 1999 |
Externally published | Yes |